Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center

Daniela Iacono, Serena Fasano, Virginia D’Abrosca, Ilenia Pantano, Gabriele Valentini Department of Clinical and Experimental Medicine, Rheumatology Section, University of Campania “Luigi Vanvitelli,” Naples, Italy Objectives: Mortality in patients with rheumatoid arthr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Iacono D, Fasano S, D'Abrosca V, Pantano I, Valentini G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Rheumatoid Arthritis Mortality Cancer Infections Cardiovascular deaths. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/602f1861b1a74e518db3c7a468b41b94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:602f1861b1a74e518db3c7a468b41b94
record_format	dspace
spelling	oai:doaj.org-article:602f1861b1a74e518db3c7a468b41b942021-12-02T03:44:30ZMortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center1179-156Xhttps://doaj.org/article/602f1861b1a74e518db3c7a468b41b942017-11-01T00:00:00Zhttps://www.dovepress.com/mortality-in-italian-patients-with-rheumatoid-arthritis-evidence-for-a-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XDaniela Iacono, Serena Fasano, Virginia D’Abrosca, Ilenia Pantano, Gabriele Valentini Department of Clinical and Experimental Medicine, Rheumatology Section, University of Campania “Luigi Vanvitelli,” Naples, Italy Objectives: Mortality in patients with rheumatoid arthritis (RA) has never been investigated in Italy. This study is devoted to investigating all the distinct causes of mortality in Italian RA patients.Methods: Clinical charts of patients consecutively admitted to an Italian tertiary center, from January 1, 2008 to December 31, 2014, were reviewed. Mortality rates (incidence mortality rate [IMR] and standardized mortality rate [SMR]) and causes of death as assessed at December 31, 2015, were registered. Mortality rates detected in our series were compared to those reported in other European cohorts and in the general Italian population.Results: Six hundred and eight patients were observed for a median of 3.51 years. Overall IMR was 0.79 deaths/100 person-years. No significant difference between our IMR and that reported in Italian population by the National Institute of Statistics was observed. All-cause and neoplasm IMRs in our series were found to be significantly lower than that reported in the Norfolk Arthritis Registry, while no difference was detected in cardiovascular (CV) mortality. On the other hand, all causes and CV SMRs in our series were found to be higher than that reported in the general Italian population, while cancer and infectious SMRs were found to be lower.Conclusion: In our series, RA patients had an increased all-cause mortality, and in particular an increased death rate due to CV. However, a lower death rate due to cancer and infections was observed. This figure might be due to the careful follow-up of RA patients in tertiary centers, and the results underlines the need to improve the management of CV risk. Keywords: rheumatoid arthritis, mortality, cancer, infections, cardiovascular deathsIacono DFasano SD'Abrosca VPantano IValentini GDove Medical PressarticleRheumatoid ArthritisMortalityCancerInfectionsCardiovascular deaths.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 9, Pp 185-189 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rheumatoid Arthritis Mortality Cancer Infections Cardiovascular deaths. Diseases of the musculoskeletal system RC925-935
spellingShingle	Rheumatoid Arthritis Mortality Cancer Infections Cardiovascular deaths. Diseases of the musculoskeletal system RC925-935 Iacono D Fasano S D'Abrosca V Pantano I Valentini G Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
description	Daniela Iacono, Serena Fasano, Virginia D’Abrosca, Ilenia Pantano, Gabriele Valentini Department of Clinical and Experimental Medicine, Rheumatology Section, University of Campania “Luigi Vanvitelli,” Naples, Italy Objectives: Mortality in patients with rheumatoid arthritis (RA) has never been investigated in Italy. This study is devoted to investigating all the distinct causes of mortality in Italian RA patients.Methods: Clinical charts of patients consecutively admitted to an Italian tertiary center, from January 1, 2008 to December 31, 2014, were reviewed. Mortality rates (incidence mortality rate [IMR] and standardized mortality rate [SMR]) and causes of death as assessed at December 31, 2015, were registered. Mortality rates detected in our series were compared to those reported in other European cohorts and in the general Italian population.Results: Six hundred and eight patients were observed for a median of 3.51 years. Overall IMR was 0.79 deaths/100 person-years. No significant difference between our IMR and that reported in Italian population by the National Institute of Statistics was observed. All-cause and neoplasm IMRs in our series were found to be significantly lower than that reported in the Norfolk Arthritis Registry, while no difference was detected in cardiovascular (CV) mortality. On the other hand, all causes and CV SMRs in our series were found to be higher than that reported in the general Italian population, while cancer and infectious SMRs were found to be lower.Conclusion: In our series, RA patients had an increased all-cause mortality, and in particular an increased death rate due to CV. However, a lower death rate due to cancer and infections was observed. This figure might be due to the careful follow-up of RA patients in tertiary centers, and the results underlines the need to improve the management of CV risk. Keywords: rheumatoid arthritis, mortality, cancer, infections, cardiovascular deaths
format	article
author	Iacono D Fasano S D'Abrosca V Pantano I Valentini G
author_facet	Iacono D Fasano S D'Abrosca V Pantano I Valentini G
author_sort	Iacono D
title	Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
title_short	Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
title_full	Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
title_fullStr	Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
title_full_unstemmed	Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
title_sort	mortality in italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/602f1861b1a74e518db3c7a468b41b94
work_keys_str_mv	AT iaconod mortalityinitalianpatientswithrheumatoidarthritisevidenceforalowmortalityratefromcancerandinfectionsinpatientsfollowedupatatertiarycenter AT fasanos mortalityinitalianpatientswithrheumatoidarthritisevidenceforalowmortalityratefromcancerandinfectionsinpatientsfollowedupatatertiarycenter AT dabroscav mortalityinitalianpatientswithrheumatoidarthritisevidenceforalowmortalityratefromcancerandinfectionsinpatientsfollowedupatatertiarycenter AT pantanoi mortalityinitalianpatientswithrheumatoidarthritisevidenceforalowmortalityratefromcancerandinfectionsinpatientsfollowedupatatertiarycenter AT valentinig mortalityinitalianpatientswithrheumatoidarthritisevidenceforalowmortalityratefromcancerandinfectionsinpatientsfollowedupatatertiarycenter
_version_	1718401631873138688

Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center

Ejemplares similares