Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties

Abstract Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of...

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Autores principales:	Iman Noshadi, Brian W. Walker, Roberto Portillo-Lara, Ehsan Shirzaei Sani, Nayara Gomes, Mohammad Reza Aziziyan, Nasim Annabi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/602fc84e3a7c4dd59a731875d951669a
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spelling	oai:doaj.org-article:602fc84e3a7c4dd59a731875d951669a2021-12-02T15:05:21ZEngineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties10.1038/s41598-017-04280-w2045-2322https://doaj.org/article/602fc84e3a7c4dd59a731875d951669a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04280-whttps://doaj.org/toc/2045-2322Abstract Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components. The engineered hydrogels could support the growth and function of primary cardiomyocytes in both two dimentinal (2D) and three dimensional (3D) cultures in vitro. Furthermore, they were shown to be efficiently biodegraded and possess low immunogenicity when implanted subcutaneously in rats. Taken together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily tailored to different biomedical and tissue engineering applications.Iman NoshadiBrian W. WalkerRoberto Portillo-LaraEhsan Shirzaei SaniNayara GomesMohammad Reza AziziyanNasim AnnabiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iman Noshadi Brian W. Walker Roberto Portillo-Lara Ehsan Shirzaei Sani Nayara Gomes Mohammad Reza Aziziyan Nasim Annabi Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
description	Abstract Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components. The engineered hydrogels could support the growth and function of primary cardiomyocytes in both two dimentinal (2D) and three dimensional (3D) cultures in vitro. Furthermore, they were shown to be efficiently biodegraded and possess low immunogenicity when implanted subcutaneously in rats. Taken together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily tailored to different biomedical and tissue engineering applications.
format	article
author	Iman Noshadi Brian W. Walker Roberto Portillo-Lara Ehsan Shirzaei Sani Nayara Gomes Mohammad Reza Aziziyan Nasim Annabi
author_facet	Iman Noshadi Brian W. Walker Roberto Portillo-Lara Ehsan Shirzaei Sani Nayara Gomes Mohammad Reza Aziziyan Nasim Annabi
author_sort	Iman Noshadi
title	Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
title_short	Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
title_full	Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
title_fullStr	Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
title_full_unstemmed	Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties
title_sort	engineering biodegradable and biocompatible bio-ionic liquid conjugated hydrogels with tunable conductivity and mechanical properties
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/602fc84e3a7c4dd59a731875d951669a
work_keys_str_mv	AT imannoshadi engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT brianwwalker engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT robertoportillolara engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT ehsanshirzaeisani engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT nayaragomes engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT mohammadrezaaziziyan engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties AT nasimannabi engineeringbiodegradableandbiocompatiblebioionicliquidconjugatedhydrogelswithtunableconductivityandmechanicalproperties
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Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties

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