IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

Our objective was to study in vitro response of blood leukocytes to IFNα2 in children with infectious mononucleosis, caused by the Epstein-Barr virus, during the acute phase of disease. Patients and methods. Sixty-five children at the age of 4 to 6 years, being in acute phase of infectious mononucle...

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Autores principales:	L. M. Kurtasova, N. A. Shakina, A. R. Schmidt
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	cell response blood leucocytes interferon epstein-barr virus Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6031f6205f994fd199da7460f07f11b2
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spelling	oai:doaj.org-article:6031f6205f994fd199da7460f07f11b22021-11-18T08:03:45ZIN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS1563-06252313-741X10.15789/1563-0625-2016-1-79-84https://doaj.org/article/6031f6205f994fd199da7460f07f11b22016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/990https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur objective was to study in vitro response of blood leukocytes to IFNα2 in children with infectious mononucleosis, caused by the Epstein-Barr virus, during the acute phase of disease. Patients and methods. Sixty-five children at the age of 4 to 6 years, being in acute phase of infectious mononucleosis caused by the Epstein-Barr virus (EBV) were under study. The control group consisted of 36 healthy children. In vitro response of blood leukocytes to IFNα2 was determined by the original technique (L.M. Kurtasova et al., 2007). Chemiluminescence of the blood leukocytes was studied according to De Sole et al. (1989). Results. We observed that clinical condition of the children with EBV infection in acute phase of the disease was characterized by decreased ranges of blood leukocyte response to IFNα2, and dependence of the cellular response on the dose, as well as severity of the disease. In conclusion, these data suggest a need for individual strategy of interferon therapy for the children with infectious mononucleosis caused by the Epstein-Barr virus.L. M. KurtasovaN. A. ShakinaA. R. SchmidtSPb RAACIarticlecell responseblood leucocytesinterferonepstein-barr virusImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 1, Pp 79-84 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	cell response blood leucocytes interferon epstein-barr virus Immunologic diseases. Allergy RC581-607
spellingShingle	cell response blood leucocytes interferon epstein-barr virus Immunologic diseases. Allergy RC581-607 L. M. Kurtasova N. A. Shakina A. R. Schmidt IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
description	Our objective was to study in vitro response of blood leukocytes to IFNα2 in children with infectious mononucleosis, caused by the Epstein-Barr virus, during the acute phase of disease. Patients and methods. Sixty-five children at the age of 4 to 6 years, being in acute phase of infectious mononucleosis caused by the Epstein-Barr virus (EBV) were under study. The control group consisted of 36 healthy children. In vitro response of blood leukocytes to IFNα2 was determined by the original technique (L.M. Kurtasova et al., 2007). Chemiluminescence of the blood leukocytes was studied according to De Sole et al. (1989). Results. We observed that clinical condition of the children with EBV infection in acute phase of the disease was characterized by decreased ranges of blood leukocyte response to IFNα2, and dependence of the cellular response on the dose, as well as severity of the disease. In conclusion, these data suggest a need for individual strategy of interferon therapy for the children with infectious mononucleosis caused by the Epstein-Barr virus.
format	article
author	L. M. Kurtasova N. A. Shakina A. R. Schmidt
author_facet	L. M. Kurtasova N. A. Shakina A. R. Schmidt
author_sort	L. M. Kurtasova
title	IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_short	IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_full	IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_fullStr	IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_full_unstemmed	IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
title_sort	in vitro cellular response to interferon-α2 in children with infectious mononucleosis caused by epstein-barr virus
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/6031f6205f994fd199da7460f07f11b2
work_keys_str_mv	AT lmkurtasova invitrocellularresponsetointerferona2inchildrenwithinfectiousmononucleosiscausedbyepsteinbarrvirus AT nashakina invitrocellularresponsetointerferona2inchildrenwithinfectiousmononucleosiscausedbyepsteinbarrvirus AT arschmidt invitrocellularresponsetointerferona2inchildrenwithinfectiousmononucleosiscausedbyepsteinbarrvirus
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IN VITRO CELLULAR RESPONSE TO INTERFERON-α2 IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS

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