Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development

Poul Jennum, Julie AE Christensen, Marielle Zoetmulder Department of Clinical Neurophysiology, Faculty of Health Sciences, Danish Center for Sleep Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia...

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Autores principales:	Jennum P, Christensen JAE, Zoetmulder M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	REM sleep Behavior Disorder electrophysiology neurophysiology polysomnography treatment Parkinson sleep Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/603a053a4a02451799ef322785661317
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spelling	oai:doaj.org-article:603a053a4a02451799ef3227856613172021-12-02T06:30:22ZNeurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development1179-1608https://doaj.org/article/603a053a4a02451799ef3227856613172016-04-01T00:00:00Zhttps://www.dovepress.com/neurophysiological-basis-of-rapid-eye-movement-sleep-behavior-disorder-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Poul Jennum, Julie AE Christensen, Marielle Zoetmulder Department of Clinical Neurophysiology, Faculty of Health Sciences, Danish Center for Sleep Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors for later development of any of the alpha-synucleinopathies: Parkinson’s disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes. Several other sleep-related abnormalities have recently been identified in patients with RBD/Parkinson’s disease who experience abnormalities in sleep electroencephalographic frequencies, sleep–wake transitions, wake and sleep stability, occurrence and morphology of sleep spindles, and electrooculography measures. These findings suggest a gradual involvement of the brainstem and other structures, which is in line with the gradual involvement known in these disorders. We propose that these findings may help identify biomarkers of individuals at high risk of subsequent conversion to parkinsonism. Keywords: motor control, brain stem, hypothalamus, hypocretinJennum PChristensen JAEZoetmulder MDove Medical PressarticleREM sleep Behavior DisorderelectrophysiologyneurophysiologypolysomnographytreatmentParkinsonsleepPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 107-120 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	REM sleep Behavior Disorder electrophysiology neurophysiology polysomnography treatment Parkinson sleep Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	REM sleep Behavior Disorder electrophysiology neurophysiology polysomnography treatment Parkinson sleep Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Jennum P Christensen JAE Zoetmulder M Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
description	Poul Jennum, Julie AE Christensen, Marielle Zoetmulder Department of Clinical Neurophysiology, Faculty of Health Sciences, Danish Center for Sleep Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors for later development of any of the alpha-synucleinopathies: Parkinson’s disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes. Several other sleep-related abnormalities have recently been identified in patients with RBD/Parkinson’s disease who experience abnormalities in sleep electroencephalographic frequencies, sleep–wake transitions, wake and sleep stability, occurrence and morphology of sleep spindles, and electrooculography measures. These findings suggest a gradual involvement of the brainstem and other structures, which is in line with the gradual involvement known in these disorders. We propose that these findings may help identify biomarkers of individuals at high risk of subsequent conversion to parkinsonism. Keywords: motor control, brain stem, hypothalamus, hypocretin
format	article
author	Jennum P Christensen JAE Zoetmulder M
author_facet	Jennum P Christensen JAE Zoetmulder M
author_sort	Jennum P
title	Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
title_short	Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
title_full	Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
title_fullStr	Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
title_full_unstemmed	Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
title_sort	neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/603a053a4a02451799ef322785661317
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Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development

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