Reorganization of mammalian body wall patterning with cloacal septation

Abstract Septation of the cloaca is a unique mammalian adaptation that required a novel reorganization of the perineum–the caudal portion of the trunk body wall not associated with the hindlimb. Fish, the basal vertebrates, separate ventrolateral body wall musculature of the trunk into two discrete...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margaret I. Hall, José R. Rodriguez-Sosa, Jeffrey H. Plochocki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/603d452f52f54257b089545737804dc4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:603d452f52f54257b089545737804dc4
record_format	dspace
spelling	oai:doaj.org-article:603d452f52f54257b089545737804dc42021-12-02T15:06:22ZReorganization of mammalian body wall patterning with cloacal septation10.1038/s41598-017-09359-y2045-2322https://doaj.org/article/603d452f52f54257b089545737804dc42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09359-yhttps://doaj.org/toc/2045-2322Abstract Septation of the cloaca is a unique mammalian adaptation that required a novel reorganization of the perineum–the caudal portion of the trunk body wall not associated with the hindlimb. Fish, the basal vertebrates, separate ventrolateral body wall musculature of the trunk into two discrete layers, while most tetrapods expand this pattern in the thorax and abdomen into four. Mammals, the only vertebrate group to divide the cloaca into urogenital and anorectal portions, exhibit complex muscle morphology in the perineum. Here we describe how perineal morphology in a broad sample of mammals fits into patterning of trunk musculature as an extension of the four-layer ventrolateral muscular patterning of the thorax and abdomen. We show that each perineal muscle layer has a specific function related to structures formed by cloacal septation. From superficial to deep, there is the subcutaneous layer, which regulates orifice closure, the external layer, which supplements both erectile and micturition function, the internal layer, which provides primary micturition and defecation regulation, and the transversus layer, which provides structural support for pelvic organs. We elucidate how the four-layer body wall pattern, restricted to the non-mammal tetrapod thorax and abdomen, is observed in the mammalian perineum to regulate function of unique perineal structures derived from cloacal septation.Margaret I. HallJosé R. Rodriguez-SosaJeffrey H. PlochockiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Margaret I. Hall José R. Rodriguez-Sosa Jeffrey H. Plochocki Reorganization of mammalian body wall patterning with cloacal septation
description	Abstract Septation of the cloaca is a unique mammalian adaptation that required a novel reorganization of the perineum–the caudal portion of the trunk body wall not associated with the hindlimb. Fish, the basal vertebrates, separate ventrolateral body wall musculature of the trunk into two discrete layers, while most tetrapods expand this pattern in the thorax and abdomen into four. Mammals, the only vertebrate group to divide the cloaca into urogenital and anorectal portions, exhibit complex muscle morphology in the perineum. Here we describe how perineal morphology in a broad sample of mammals fits into patterning of trunk musculature as an extension of the four-layer ventrolateral muscular patterning of the thorax and abdomen. We show that each perineal muscle layer has a specific function related to structures formed by cloacal septation. From superficial to deep, there is the subcutaneous layer, which regulates orifice closure, the external layer, which supplements both erectile and micturition function, the internal layer, which provides primary micturition and defecation regulation, and the transversus layer, which provides structural support for pelvic organs. We elucidate how the four-layer body wall pattern, restricted to the non-mammal tetrapod thorax and abdomen, is observed in the mammalian perineum to regulate function of unique perineal structures derived from cloacal septation.
format	article
author	Margaret I. Hall José R. Rodriguez-Sosa Jeffrey H. Plochocki
author_facet	Margaret I. Hall José R. Rodriguez-Sosa Jeffrey H. Plochocki
author_sort	Margaret I. Hall
title	Reorganization of mammalian body wall patterning with cloacal septation
title_short	Reorganization of mammalian body wall patterning with cloacal septation
title_full	Reorganization of mammalian body wall patterning with cloacal septation
title_fullStr	Reorganization of mammalian body wall patterning with cloacal septation
title_full_unstemmed	Reorganization of mammalian body wall patterning with cloacal septation
title_sort	reorganization of mammalian body wall patterning with cloacal septation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/603d452f52f54257b089545737804dc4
work_keys_str_mv	AT margaretihall reorganizationofmammalianbodywallpatterningwithcloacalseptation AT joserrodriguezsosa reorganizationofmammalianbodywallpatterningwithcloacalseptation AT jeffreyhplochocki reorganizationofmammalianbodywallpatterningwithcloacalseptation
_version_	1718388452034084864

Reorganization of mammalian body wall patterning with cloacal septation

Ejemplares similares