Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

The inhibitory synaptic protein collybistin (CB) and GABAAR-α subunits are thought to interact, but strength and specificity are unclear. Here the authors study the CB–α2 interaction and show that a mouse mutated in the CB-binding region of α2 displays a loss of specific synapses and seizure.

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Main Authors:	Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/603d64a78c594cd6a9206450bd9f2e4e
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spelling	oai:doaj.org-article:603d64a78c594cd6a9206450bd9f2e4e2021-12-02T14:38:48ZDevelopmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin10.1038/s41467-018-05481-12041-1723https://doaj.org/article/603d64a78c594cd6a9206450bd9f2e4e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05481-1https://doaj.org/toc/2041-1723The inhibitory synaptic protein collybistin (CB) and GABAAR-α subunits are thought to interact, but strength and specificity are unclear. Here the authors study the CB–α2 interaction and show that a mouse mutated in the CB-binding region of α2 displays a loss of specific synapses and seizure.Rochelle M. HinesHans Michael MaricDustin J. HinesAmit ModgilPatrizia PanzanelliYasuko NakamuraAnna J. NathansonAlan CrossTarek DeebNicholas J. BrandonPaul DaviesJean-Marc FritschyHermann SchindelinStephen J. MossNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rochelle M. Hines Hans Michael Maric Dustin J. Hines Amit Modgil Patrizia Panzanelli Yasuko Nakamura Anna J. Nathanson Alan Cross Tarek Deeb Nicholas J. Brandon Paul Davies Jean-Marc Fritschy Hermann Schindelin Stephen J. Moss Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
description	The inhibitory synaptic protein collybistin (CB) and GABAAR-α subunits are thought to interact, but strength and specificity are unclear. Here the authors study the CB–α2 interaction and show that a mouse mutated in the CB-binding region of α2 displays a loss of specific synapses and seizure.
format	article
author	Rochelle M. Hines Hans Michael Maric Dustin J. Hines Amit Modgil Patrizia Panzanelli Yasuko Nakamura Anna J. Nathanson Alan Cross Tarek Deeb Nicholas J. Brandon Paul Davies Jean-Marc Fritschy Hermann Schindelin Stephen J. Moss
author_facet	Rochelle M. Hines Hans Michael Maric Dustin J. Hines Amit Modgil Patrizia Panzanelli Yasuko Nakamura Anna J. Nathanson Alan Cross Tarek Deeb Nicholas J. Brandon Paul Davies Jean-Marc Fritschy Hermann Schindelin Stephen J. Moss
author_sort	Rochelle M. Hines
title	Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
title_short	Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
title_full	Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
title_fullStr	Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
title_full_unstemmed	Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin
title_sort	developmental seizures and mortality result from reducing gabaa receptor α2-subunit interaction with collybistin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/603d64a78c594cd6a9206450bd9f2e4e
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Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

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