Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

The inhibitory synaptic protein collybistin (CB) and GABAAR-α subunits are thought to interact, but strength and specificity are unclear. Here the authors study the CB–α2 interaction and show that a mouse mutated in the CB-binding region of α2 displays a loss of specific synapses and seizure.

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Detalles Bibliográficos
Autores principales: Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/603d64a78c594cd6a9206450bd9f2e4e
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