Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers

Abstract Magnetic resonance elastography (MRE) is a reliable noninvasive method for assessment of hepatic stiffness. Liver stiffness is known to be affected by elevated postprandial portal blood flow in patients with chronic liver disease. The goal of this study was to determine whether food intake...

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Autores principales:	Marzanna Obrzut, Vitaliy Atamaniuk, Jun Chen, Bogdan Obrzut, Richard L. Ehman, Marian Cholewa, Agnieszka Palusińska, Krzysztof Gutkowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/603dd7bcf0494d0c83aee4d3e216b382
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spelling	oai:doaj.org-article:603dd7bcf0494d0c83aee4d3e216b3822021-12-02T17:13:18ZPostprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers10.1038/s41598-021-99243-72045-2322https://doaj.org/article/603dd7bcf0494d0c83aee4d3e216b3822021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99243-7https://doaj.org/toc/2045-2322Abstract Magnetic resonance elastography (MRE) is a reliable noninvasive method for assessment of hepatic stiffness. Liver stiffness is known to be affected by elevated postprandial portal blood flow in patients with chronic liver disease. The goal of this study was to determine whether food intake affects liver stiffness in the absence of known liver disease. We evaluated 100 volunteers (35 men and 65 women) who met inclusion criteria. The subjects had two MRE examinations, first while fasting and then 30 min after a test meal. Fourteen subjects also had two additional MRE exams 1 h 30 min and 2 h 30 min after the meal. Liver stiffness was measured by placing the largest possible polygon ROIs on the four widest liver slices and calculated as a mean of stiffness values from each slice. The correlation of liver stiffness values before and after the meal was assessed using a paired t-test. To evaluate the relationship between the change in postprandial liver stiffness and fasting liver stiffness values, linear regression was performed. The liver stiffness values in the fasting state ranged from 1.84 to 2.82 kPa, with a mean of 2.30 ± 0.23 kPa (95% CI 2.25–2.34). At 30 min after the meal, liver stiffness values ranged from 2.12 to 3.50 kPa, with a mean of 2.70 ± 0.28 kPa (95% CI 2.64–2.75), demonstrating a systematic postprandial increase by 0.40 ± 0.23 kPa (17.7 ± 3.5%). Meal intake significantly increases liver stiffness in healthy individuals, which persists for at least 2 h 30 min. Patients should fast for 3–4 h before MRE examinations to avoid fibrosis overstaging due to postprandial liver stiffness augmentation.Marzanna ObrzutVitaliy AtamaniukJun ChenBogdan ObrzutRichard L. EhmanMarian CholewaAgnieszka PalusińskaKrzysztof GutkowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marzanna Obrzut Vitaliy Atamaniuk Jun Chen Bogdan Obrzut Richard L. Ehman Marian Cholewa Agnieszka Palusińska Krzysztof Gutkowski Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
description	Abstract Magnetic resonance elastography (MRE) is a reliable noninvasive method for assessment of hepatic stiffness. Liver stiffness is known to be affected by elevated postprandial portal blood flow in patients with chronic liver disease. The goal of this study was to determine whether food intake affects liver stiffness in the absence of known liver disease. We evaluated 100 volunteers (35 men and 65 women) who met inclusion criteria. The subjects had two MRE examinations, first while fasting and then 30 min after a test meal. Fourteen subjects also had two additional MRE exams 1 h 30 min and 2 h 30 min after the meal. Liver stiffness was measured by placing the largest possible polygon ROIs on the four widest liver slices and calculated as a mean of stiffness values from each slice. The correlation of liver stiffness values before and after the meal was assessed using a paired t-test. To evaluate the relationship between the change in postprandial liver stiffness and fasting liver stiffness values, linear regression was performed. The liver stiffness values in the fasting state ranged from 1.84 to 2.82 kPa, with a mean of 2.30 ± 0.23 kPa (95% CI 2.25–2.34). At 30 min after the meal, liver stiffness values ranged from 2.12 to 3.50 kPa, with a mean of 2.70 ± 0.28 kPa (95% CI 2.64–2.75), demonstrating a systematic postprandial increase by 0.40 ± 0.23 kPa (17.7 ± 3.5%). Meal intake significantly increases liver stiffness in healthy individuals, which persists for at least 2 h 30 min. Patients should fast for 3–4 h before MRE examinations to avoid fibrosis overstaging due to postprandial liver stiffness augmentation.
format	article
author	Marzanna Obrzut Vitaliy Atamaniuk Jun Chen Bogdan Obrzut Richard L. Ehman Marian Cholewa Agnieszka Palusińska Krzysztof Gutkowski
author_facet	Marzanna Obrzut Vitaliy Atamaniuk Jun Chen Bogdan Obrzut Richard L. Ehman Marian Cholewa Agnieszka Palusińska Krzysztof Gutkowski
author_sort	Marzanna Obrzut
title	Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
title_short	Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
title_full	Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
title_fullStr	Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
title_full_unstemmed	Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
title_sort	postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/603dd7bcf0494d0c83aee4d3e216b382
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Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers

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