Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to...

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Autores principales: Tom Sidwell, Yang Liao, Alexandra L. Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P. Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R. Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K. Smyth, Wei Shi, Axel Kallies
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
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Sumario:The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.

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