Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to...

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Autores principales:	Tom Sidwell, Yang Liao, Alexandra L. Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P. Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R. Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K. Smyth, Wei Shi, Axel Kallies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
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spelling	oai:doaj.org-article:603dfe4ffed14153a4ca1bede6c41d3e2021-12-02T14:42:46ZAttenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis10.1038/s41467-019-14112-22041-1723https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14112-2https://doaj.org/toc/2041-1723The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.Tom SidwellYang LiaoAlexandra L. GarnhamAjithkumar VasanthakumarRenee GlouryJonas BlumePeggy P. TehDavid ChisangaChristoph ThelemannFabian de Labastida RiveraChristian R. EngwerdaLynn CorcoranKohei KometaniTomohiro KurosakiGordon K. SmythWei ShiAxel KalliesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
description	The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to TCR signaling.
format	article
author	Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies
author_facet	Tom Sidwell Yang Liao Alexandra L. Garnham Ajithkumar Vasanthakumar Renee Gloury Jonas Blume Peggy P. Teh David Chisanga Christoph Thelemann Fabian de Labastida Rivera Christian R. Engwerda Lynn Corcoran Kohei Kometani Tomohiro Kurosaki Gordon K. Smyth Wei Shi Axel Kallies
author_sort	Tom Sidwell
title	Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
title_short	Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
title_full	Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
title_fullStr	Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
title_full_unstemmed	Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
title_sort	attenuation of tcr-induced transcription by bach2 controls regulatory t cell differentiation and homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
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Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

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