Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease

Perianal fistula in patients with Crohn’s disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of m...

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Autores principales:	Marcin Włodarczyk, Katarzyna Czerwińska, Jakub Włodarczyk, Jakub Fichna, Adam Dziki, Łukasz Dziki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stem cells perianal fistula Crohn’s disease perianal Crohn’s disease Science Q
Acceso en línea:	https://doaj.org/article/60411e0b87704d12b829309ab37e4fcf
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spelling	oai:doaj.org-article:60411e0b87704d12b829309ab37e4fcf2021-11-25T18:10:32ZCurrent Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease10.3390/life111111332075-1729https://doaj.org/article/60411e0b87704d12b829309ab37e4fcf2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1133https://doaj.org/toc/2075-1729Perianal fistula in patients with Crohn’s disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of mesenchymal stem cells (MSCs) in perianal Crohn’s disease have been published. Although to this day there are no clear guidelines determining optimal dosage, injections frequency and culture conditions, their efficiency has proven to be much higher than conventionally used methods. According to studies, they can effectively induce as well as maintain fistula closure. This approach also avoids common side effects related to conventional surgical treatment.Marcin WłodarczykKatarzyna CzerwińskaJakub WłodarczykJakub FichnaAdam DzikiŁukasz DzikiMDPI AGarticlemesenchymal stem cellsperianal fistulaCrohn’s diseaseperianal Crohn’s diseaseScienceQENLife, Vol 11, Iss 1133, p 1133 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells perianal fistula Crohn’s disease perianal Crohn’s disease Science Q
spellingShingle	mesenchymal stem cells perianal fistula Crohn’s disease perianal Crohn’s disease Science Q Marcin Włodarczyk Katarzyna Czerwińska Jakub Włodarczyk Jakub Fichna Adam Dziki Łukasz Dziki Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
description	Perianal fistula in patients with Crohn’s disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of mesenchymal stem cells (MSCs) in perianal Crohn’s disease have been published. Although to this day there are no clear guidelines determining optimal dosage, injections frequency and culture conditions, their efficiency has proven to be much higher than conventionally used methods. According to studies, they can effectively induce as well as maintain fistula closure. This approach also avoids common side effects related to conventional surgical treatment.
format	article
author	Marcin Włodarczyk Katarzyna Czerwińska Jakub Włodarczyk Jakub Fichna Adam Dziki Łukasz Dziki
author_facet	Marcin Włodarczyk Katarzyna Czerwińska Jakub Włodarczyk Jakub Fichna Adam Dziki Łukasz Dziki
author_sort	Marcin Włodarczyk
title	Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
title_short	Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
title_full	Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
title_fullStr	Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
title_full_unstemmed	Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease
title_sort	current overview on the use of mesenchymal stem cells for perianal fistula treatment in patients with crohn’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60411e0b87704d12b829309ab37e4fcf
work_keys_str_mv	AT marcinwłodarczyk currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease AT katarzynaczerwinska currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease AT jakubwłodarczyk currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease AT jakubfichna currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease AT adamdziki currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease AT łukaszdziki currentoverviewontheuseofmesenchymalstemcellsforperianalfistulatreatmentinpatientswithcrohnsdisease
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Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease

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