Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone

Abstract In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate...

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Autores principales:	Chia-Chu Liu, Shu-Pin Huang, Kai-Hung Cheng, Tusty-Jiuan Hsieh, Chun-Nung Huang, Chii-Jye Wang, Hsin-Chih Yeh, Chia-Chun Tsai, Bo-Ying Bao, Wen-Jeng Wu, Yung-Chin Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6042ff1c22af4ea2a5ffcb623fc97674
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spelling	oai:doaj.org-article:6042ff1c22af4ea2a5ffcb623fc976742021-12-02T15:05:11ZLower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone10.1038/s41598-017-03078-02045-2322https://doaj.org/article/6042ff1c22af4ea2a5ffcb623fc976742017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03078-0https://doaj.org/toc/2045-2322Abstract In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in 614 Taiwanese men over 40 years old collected from a free health screening. Subjects in the lowest quartile of TT and SHBG levels are exposed to a 1.58 and 3.22 times risk of developing MetS, as compared to those in the highest quartile of TT and SHBG levels. However, SHBG retains its significance independent of TT as a MetS risk predictor, but not vice versa. In addition, SHBG was significantly correlated with both adiponectin and leptin levels even after adjusting for TT levels. In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.Chia-Chu LiuShu-Pin HuangKai-Hung ChengTusty-Jiuan HsiehChun-Nung HuangChii-Jye WangHsin-Chih YehChia-Chun TsaiBo-Ying BaoWen-Jeng WuYung-Chin LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Chu Liu Shu-Pin Huang Kai-Hung Cheng Tusty-Jiuan Hsieh Chun-Nung Huang Chii-Jye Wang Hsin-Chih Yeh Chia-Chun Tsai Bo-Ying Bao Wen-Jeng Wu Yung-Chin Lee Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
description	Abstract In addition to testosterone (T), the emerging role of sex hormone-binding globulin (SHBG) in pathogenesis of metabolic syndrome (MetS) has been noted recently. However, reports of associations with serum adipocytokine levels are still limited. Therefore, we conducted this study to evaluate whether serum T and SHBG levels are independent predictors for the risk of MetS that are associated with adiponectin and leptin levels in 614 Taiwanese men over 40 years old collected from a free health screening. Subjects in the lowest quartile of TT and SHBG levels are exposed to a 1.58 and 3.22 times risk of developing MetS, as compared to those in the highest quartile of TT and SHBG levels. However, SHBG retains its significance independent of TT as a MetS risk predictor, but not vice versa. In addition, SHBG was significantly correlated with both adiponectin and leptin levels even after adjusting for TT levels. In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
format	article
author	Chia-Chu Liu Shu-Pin Huang Kai-Hung Cheng Tusty-Jiuan Hsieh Chun-Nung Huang Chii-Jye Wang Hsin-Chih Yeh Chia-Chun Tsai Bo-Ying Bao Wen-Jeng Wu Yung-Chin Lee
author_facet	Chia-Chu Liu Shu-Pin Huang Kai-Hung Cheng Tusty-Jiuan Hsieh Chun-Nung Huang Chii-Jye Wang Hsin-Chih Yeh Chia-Chun Tsai Bo-Ying Bao Wen-Jeng Wu Yung-Chin Lee
author_sort	Chia-Chu Liu
title	Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
title_short	Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
title_full	Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
title_fullStr	Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
title_full_unstemmed	Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
title_sort	lower shbg level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6042ff1c22af4ea2a5ffcb623fc97674
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Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone

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