Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study

Current treatment for canine bacterial pneumonia relies on protracted courses of antimicrobials (3–6 weeks or more) with recommendations to continue for 1–2 weeks past resolution of all clinical and thoracic radiographic abnormalities. However, in humans, bacterial pneumonia is often treated with 5–...

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Autores principales:	Aida I. Vientós-Plotts, Isabelle Masseau, Carol R. Reinero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	community-acquired pneumonia aspiration pneumonia global radiographic score thoracic imaging bacterial culture Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/60446df6635d4de59412df3b1fa060a1
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spelling	oai:doaj.org-article:60446df6635d4de59412df3b1fa060a12021-11-25T16:15:10ZComparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study10.3390/ani111130962076-2615https://doaj.org/article/60446df6635d4de59412df3b1fa060a12021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3096https://doaj.org/toc/2076-2615Current treatment for canine bacterial pneumonia relies on protracted courses of antimicrobials (3–6 weeks or more) with recommendations to continue for 1–2 weeks past resolution of all clinical and thoracic radiographic abnormalities. However, in humans, bacterial pneumonia is often treated with 5–10-day courses of antimicrobials, and thoracic radiographs are not considered useful to guide therapeutic duration. The primary study objective was to determine whether a short course of antimicrobials would be sufficient to treat canine bacterial pneumonia. Eight dogs with uncomplicated bacterial pneumonia were enrolled in this randomized, double-blinded, placebo-controlled study comparing clinical and radiographic resolution with differing durations of antimicrobial therapy. Dogs received a course of antimicrobials lasting 10 (A10) or 21 (A21) days. Dogs randomized to the A10 group received placebo for 11 days following antimicrobial therapy. Patients were evaluated at presentation and 10, 30 and 60 days after the initiation of antimicrobials. At 10 days, 6/8 dogs had resolution of both clinical signs and inflammatory leukogram, and 5/8 dogs had improved global radiographic scores. After 60 days, clinical and hematologic resolution of pneumonia was noted in all dogs regardless of antimicrobial therapy duration; however, 3/8 dogs had persistent radiographic lesions. Thoracic radiographs do not appear to be a reliable marker to guide antimicrobial therapy in canine bacterial pneumonia as radiographic lesions may lag or persist despite clinical cure. This pilot study suggests a 10-day course of antimicrobials may be sufficient to treat uncomplicated canine bacterial pneumonia.Aida I. Vientós-PlottsIsabelle MasseauCarol R. ReineroMDPI AGarticlecommunity-acquired pneumoniaaspiration pneumoniaglobal radiographic scorethoracic imagingbacterial cultureVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3096, p 3096 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	community-acquired pneumonia aspiration pneumonia global radiographic score thoracic imaging bacterial culture Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	community-acquired pneumonia aspiration pneumonia global radiographic score thoracic imaging bacterial culture Veterinary medicine SF600-1100 Zoology QL1-991 Aida I. Vientós-Plotts Isabelle Masseau Carol R. Reinero Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
description	Current treatment for canine bacterial pneumonia relies on protracted courses of antimicrobials (3–6 weeks or more) with recommendations to continue for 1–2 weeks past resolution of all clinical and thoracic radiographic abnormalities. However, in humans, bacterial pneumonia is often treated with 5–10-day courses of antimicrobials, and thoracic radiographs are not considered useful to guide therapeutic duration. The primary study objective was to determine whether a short course of antimicrobials would be sufficient to treat canine bacterial pneumonia. Eight dogs with uncomplicated bacterial pneumonia were enrolled in this randomized, double-blinded, placebo-controlled study comparing clinical and radiographic resolution with differing durations of antimicrobial therapy. Dogs received a course of antimicrobials lasting 10 (A10) or 21 (A21) days. Dogs randomized to the A10 group received placebo for 11 days following antimicrobial therapy. Patients were evaluated at presentation and 10, 30 and 60 days after the initiation of antimicrobials. At 10 days, 6/8 dogs had resolution of both clinical signs and inflammatory leukogram, and 5/8 dogs had improved global radiographic scores. After 60 days, clinical and hematologic resolution of pneumonia was noted in all dogs regardless of antimicrobial therapy duration; however, 3/8 dogs had persistent radiographic lesions. Thoracic radiographs do not appear to be a reliable marker to guide antimicrobial therapy in canine bacterial pneumonia as radiographic lesions may lag or persist despite clinical cure. This pilot study suggests a 10-day course of antimicrobials may be sufficient to treat uncomplicated canine bacterial pneumonia.
format	article
author	Aida I. Vientós-Plotts Isabelle Masseau Carol R. Reinero
author_facet	Aida I. Vientós-Plotts Isabelle Masseau Carol R. Reinero
author_sort	Aida I. Vientós-Plotts
title	Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
title_short	Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
title_full	Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
title_fullStr	Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
title_full_unstemmed	Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study
title_sort	comparison of short- versus long-course antimicrobial therapy of uncomplicated bacterial pneumonia in dogs: a double-blinded, placebo-controlled pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60446df6635d4de59412df3b1fa060a1
work_keys_str_mv	AT aidaivientosplotts comparisonofshortversuslongcourseantimicrobialtherapyofuncomplicatedbacterialpneumoniaindogsadoubleblindedplacebocontrolledpilotstudy AT isabellemasseau comparisonofshortversuslongcourseantimicrobialtherapyofuncomplicatedbacterialpneumoniaindogsadoubleblindedplacebocontrolledpilotstudy AT carolrreinero comparisonofshortversuslongcourseantimicrobialtherapyofuncomplicatedbacterialpneumoniaindogsadoubleblindedplacebocontrolledpilotstudy
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Comparison of Short- versus Long-Course Antimicrobial Therapy of Uncomplicated Bacterial Pneumonia in Dogs: A Double-Blinded, Placebo-Controlled Pilot Study

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