Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity

Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically...

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Autores principales:	Astrid Hubert, Andreas Seitz, Valeria Martínez Pereyra, Raffi Bekeredjian, Udo Sechtem, Peter Ong
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6044c2c127c44d8d9732f70601633be7
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id	oai:doaj.org-article:6044c2c127c44d8d9732f70601633be7
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spelling	oai:doaj.org-article:6044c2c127c44d8d9732f70601633be72021-12-04T16:02:34ZCoronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity10.15420/ecr.2019.201758-37641758-3756https://doaj.org/article/6044c2c127c44d8d9732f70601633be72020-03-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2019.20https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically unobstructed coronary arteries. CAS may occur at the epicardial level and/or in the microvasculature. Although the underlying pathophysiological mechanisms of CAS are still largely unclear, endothelial dysfunction and vascular smooth muscle cell (VSMC) hyperreactivity seem to be involved as major players, although their contribution to induce CAS is still seen as controversial. This article will look at the role and possible mechanistic interplay between an impaired endothelial and VSMC function in the pathogenesis of CAS.Astrid HubertAndreas SeitzValeria Martínez PereyraRaffi BekeredjianUdo SechtemPeter OngRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 15, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
description	Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically unobstructed coronary arteries. CAS may occur at the epicardial level and/or in the microvasculature. Although the underlying pathophysiological mechanisms of CAS are still largely unclear, endothelial dysfunction and vascular smooth muscle cell (VSMC) hyperreactivity seem to be involved as major players, although their contribution to induce CAS is still seen as controversial. This article will look at the role and possible mechanistic interplay between an impaired endothelial and VSMC function in the pathogenesis of CAS.
format	article
author	Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong
author_facet	Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong
author_sort	Astrid Hubert
title	Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
title_short	Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
title_full	Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
title_fullStr	Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
title_full_unstemmed	Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
title_sort	coronary artery spasm: the interplay between endothelial dysfunction and vascular smooth muscle cell hyperreactivity
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/6044c2c127c44d8d9732f70601633be7
work_keys_str_mv	AT astridhubert coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity AT andreasseitz coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity AT valeriamartinezpereyra coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity AT raffibekeredjian coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity AT udosechtem coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity AT peterong coronaryarteryspasmtheinterplaybetweenendothelialdysfunctionandvascularsmoothmusclecellhyperreactivity
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Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity

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