Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions

The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have poten...

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Autores principales:	Maura Harrigan, Courtney McGowan, Annette Hood, Leah M. Ferrucci, ThaiHien Nguyen, Brenda Cartmel, Fang-Yong Li, Melinda L. Irwin, Tara Sanft
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dietary supplements interactions tamoxifen aromatase inhibitors breast cancer survivors natural medicine Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6047a53df20342239f733b7280464583
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spelling	oai:doaj.org-article:6047a53df20342239f733b72804645832021-11-25T18:33:34ZDietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions10.3390/nu131137302072-6643https://doaj.org/article/6047a53df20342239f733b72804645832021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3730https://doaj.org/toc/2072-6643The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 2010 and 2017. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.Maura HarriganCourtney McGowanAnnette HoodLeah M. FerrucciThaiHien NguyenBrenda CartmelFang-Yong LiMelinda L. IrwinTara SanftMDPI AGarticledietary supplementsinteractionstamoxifenaromatase inhibitorsbreast cancer survivorsnatural medicineNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3730, p 3730 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dietary supplements interactions tamoxifen aromatase inhibitors breast cancer survivors natural medicine Nutrition. Foods and food supply TX341-641
spellingShingle	dietary supplements interactions tamoxifen aromatase inhibitors breast cancer survivors natural medicine Nutrition. Foods and food supply TX341-641 Maura Harrigan Courtney McGowan Annette Hood Leah M. Ferrucci ThaiHien Nguyen Brenda Cartmel Fang-Yong Li Melinda L. Irwin Tara Sanft Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
description	The use of dietary supplements is common in the general population and even more prevalent among cancer survivors. The World Cancer Research Fund/American Institute for Cancer Research specifies that dietary supplements should not be used for cancer prevention. Several dietary supplements have potential pharmacokinetic and pharmacodynamic interactions that may change their clinical efficacy or potentiate adverse effects of the adjuvant endocrine therapy prescribed for breast cancer treatment. This analysis examined the prevalence of self-reported dietary supplement use and the potential interactions with tamoxifen and aromatase inhibitors (AIs) among breast cancer survivors enrolled in three randomized controlled trials of lifestyle interventions conducted between 2010 and 2017. The potential interactions with tamoxifen and AIs were identified using the Natural Medicine Database. Among 475 breast cancer survivors (2.9 (mean) or 2.5 (standard deviation) years from diagnosis), 393 (83%) reported using dietary supplements. A total of 108 different types of dietary supplements were reported and 36 potential adverse interactions with tamoxifen or AIs were identified. Among the 353 women taking tamoxifen or AIs, 38% were taking dietary supplements with a potential risk of interactions. We observed a high prevalence of dietary supplement use among breast cancer survivors and the potential for adverse interactions between the prescribed endocrine therapy and dietary supplements was common.
format	article
author	Maura Harrigan Courtney McGowan Annette Hood Leah M. Ferrucci ThaiHien Nguyen Brenda Cartmel Fang-Yong Li Melinda L. Irwin Tara Sanft
author_facet	Maura Harrigan Courtney McGowan Annette Hood Leah M. Ferrucci ThaiHien Nguyen Brenda Cartmel Fang-Yong Li Melinda L. Irwin Tara Sanft
author_sort	Maura Harrigan
title	Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
title_short	Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
title_full	Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
title_fullStr	Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
title_full_unstemmed	Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
title_sort	dietary supplement use and interactions with tamoxifen and aromatase inhibitors in breast cancer survivors enrolled in lifestyle interventions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6047a53df20342239f733b7280464583
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Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions

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