Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion

Yuka Ito, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Taichiro Miyake, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan Purpose: Our aim was to compare the 1 year efficacy and safety results of intravitreal b...

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Autores principales:	Ito Y, Saishin Y, Sawada O, Kakinoki M, Miyake T, Sawada T, Kawamura H, Ohji M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/604c552af1e746f9a137bdd8fe3b66b9
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spelling	oai:doaj.org-article:604c552af1e746f9a137bdd8fe3b66b92021-12-02T03:50:42ZComparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion1177-5483https://doaj.org/article/604c552af1e746f9a137bdd8fe3b66b92015-01-01T00:00:00Zhttp://www.dovepress.com/comparison-of-single-injection-and-three-monthly-injections-of-intravi-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Yuka Ito, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Taichiro Miyake, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan Purpose: Our aim was to compare the 1 year efficacy and safety results of intravitreal bevacizumab (IVB) in two prospective, consecutive groups of patients with macular edema (ME) following branch retinal vein occlusion (BRVO).Patients and methods: Twenty-five eyes with ME after BRVO received one IVB injection (single-injection group) and 27 eyes received three monthly IVB injections (three-injection group). Both groups were followed monthly for 12 months. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Patients were eligible to receive an IVB injection if the mean CFT increased 100 µm or more or the BCVA decreased 0.1 logarithm of the minimum angle of resolution (logMAR) unit or more compared with values measured on the last visit.Results: The mean logMAR BCVA and CFT, respectively, improved from 0.56 to 0.33 and from 598 µm to 348 µm in the single-injection group (P<0.001) and from 0.55 to 0.26 and from 514 µm to 293 µm in the three-injection group (P<0.001). During the study period, the mean total number of injections was significantly smaller in the single-injection group than in the three-injection group (2.1 and 4.3, respectively, P<0.001). No serious complications related to the IVB injections developed in either group.Conclusion: The single-injection group achieved similar visual outcomes for ME secondary to BRVO with fewer injections compared with the three-injection group. Keywords: branch retinal vein occlusion, bevacizumab, single intravitreal injection, three monthly intravitreal injectionsIto YSaishin YSawada OKakinoki MMiyake TSawada TKawamura HOhji MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 175-180 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ito Y Saishin Y Sawada O Kakinoki M Miyake T Sawada T Kawamura H Ohji M Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
description	Yuka Ito, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Taichiro Miyake, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan Purpose: Our aim was to compare the 1 year efficacy and safety results of intravitreal bevacizumab (IVB) in two prospective, consecutive groups of patients with macular edema (ME) following branch retinal vein occlusion (BRVO).Patients and methods: Twenty-five eyes with ME after BRVO received one IVB injection (single-injection group) and 27 eyes received three monthly IVB injections (three-injection group). Both groups were followed monthly for 12 months. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Patients were eligible to receive an IVB injection if the mean CFT increased 100 µm or more or the BCVA decreased 0.1 logarithm of the minimum angle of resolution (logMAR) unit or more compared with values measured on the last visit.Results: The mean logMAR BCVA and CFT, respectively, improved from 0.56 to 0.33 and from 598 µm to 348 µm in the single-injection group (P<0.001) and from 0.55 to 0.26 and from 514 µm to 293 µm in the three-injection group (P<0.001). During the study period, the mean total number of injections was significantly smaller in the single-injection group than in the three-injection group (2.1 and 4.3, respectively, P<0.001). No serious complications related to the IVB injections developed in either group.Conclusion: The single-injection group achieved similar visual outcomes for ME secondary to BRVO with fewer injections compared with the three-injection group. Keywords: branch retinal vein occlusion, bevacizumab, single intravitreal injection, three monthly intravitreal injections
format	article
author	Ito Y Saishin Y Sawada O Kakinoki M Miyake T Sawada T Kawamura H Ohji M
author_facet	Ito Y Saishin Y Sawada O Kakinoki M Miyake T Sawada T Kawamura H Ohji M
author_sort	Ito Y
title	Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
title_short	Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
title_full	Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
title_fullStr	Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
title_full_unstemmed	Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
title_sort	comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/604c552af1e746f9a137bdd8fe3b66b9
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Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion

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