Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures

Abstract Endothelial defects (ED) and the usage of interposition vein grafts (IVG) are known risk factors for free flap failure. This experimental study aimed to compare both situations of thrombus formation and fluorescence angiographic behavior. Indocyanine green videoangiography (ICGVA) with the...

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Autores principales:	Lucas M. Ritschl, Marie-Kristin Hofmann, Constantin T. Wolff, Leonard H. Schmidt, Klaus-Dietrich Wolff, Andreas M. Fichter, Thomas Mücke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/604d215bc79340189ade29e650598290
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spelling	oai:doaj.org-article:604d215bc79340189ade29e6505982902021-12-02T15:27:12ZEffects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures10.1038/s41598-021-88324-22045-2322https://doaj.org/article/604d215bc79340189ade29e6505982902021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88324-2https://doaj.org/toc/2045-2322Abstract Endothelial defects (ED) and the usage of interposition vein grafts (IVG) are known risk factors for free flap failure. This experimental study aimed to compare both situations of thrombus formation and fluorescence angiographic behavior. Indocyanine green videoangiography (ICGVA) with the FLOW 800 tool was systematically performed in groups I = ED, II = IVG, and III = ED and IVG (each n = 11). ICGVA was able to detect thrombosis in five animals and safely ruled it out in 26 with two false-positive cases (sensitivity, specificity, and positive and negative predictive values were 100%, 90%, 62%, and 100%, respectively). The difference between visually and ICGVA-assisted ED measurements was significant (p = 0.04). The areas of thrombosis showed no significant difference. Moreover, ICGVA detected a decrease of all parameters at the ED area and/or within the IVG section in all groups. The presence of an endothelial defect had a higher impact on thrombus formation than the IVG usage. ICGVA is qualitatively able to detect endothelial defects and clinically evident thrombosis. However, the quantitative values are not yet attributable to one of the clinical scenarios that may jeopardize free flap transfer.Lucas M. RitschlMarie-Kristin HofmannConstantin T. WolffLeonard H. SchmidtKlaus-Dietrich WolffAndreas M. FichterThomas MückeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lucas M. Ritschl Marie-Kristin Hofmann Constantin T. Wolff Leonard H. Schmidt Klaus-Dietrich Wolff Andreas M. Fichter Thomas Mücke Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
description	Abstract Endothelial defects (ED) and the usage of interposition vein grafts (IVG) are known risk factors for free flap failure. This experimental study aimed to compare both situations of thrombus formation and fluorescence angiographic behavior. Indocyanine green videoangiography (ICGVA) with the FLOW 800 tool was systematically performed in groups I = ED, II = IVG, and III = ED and IVG (each n = 11). ICGVA was able to detect thrombosis in five animals and safely ruled it out in 26 with two false-positive cases (sensitivity, specificity, and positive and negative predictive values were 100%, 90%, 62%, and 100%, respectively). The difference between visually and ICGVA-assisted ED measurements was significant (p = 0.04). The areas of thrombosis showed no significant difference. Moreover, ICGVA detected a decrease of all parameters at the ED area and/or within the IVG section in all groups. The presence of an endothelial defect had a higher impact on thrombus formation than the IVG usage. ICGVA is qualitatively able to detect endothelial defects and clinically evident thrombosis. However, the quantitative values are not yet attributable to one of the clinical scenarios that may jeopardize free flap transfer.
format	article
author	Lucas M. Ritschl Marie-Kristin Hofmann Constantin T. Wolff Leonard H. Schmidt Klaus-Dietrich Wolff Andreas M. Fichter Thomas Mücke
author_facet	Lucas M. Ritschl Marie-Kristin Hofmann Constantin T. Wolff Leonard H. Schmidt Klaus-Dietrich Wolff Andreas M. Fichter Thomas Mücke
author_sort	Lucas M. Ritschl
title	Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
title_short	Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
title_full	Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
title_fullStr	Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
title_full_unstemmed	Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
title_sort	effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/604d215bc79340189ade29e650598290
work_keys_str_mv	AT lucasmritschl effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT mariekristinhofmann effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT constantintwolff effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT leonardhschmidt effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT klausdietrichwolff effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT andreasmfichter effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures AT thomasmucke effectsofendothelialdefectsandvenousinterpositiongraftsontheacuteincidenceofthrombusformationwithinmicrovascularprocedures
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Effects of endothelial defects and venous interposition grafts on the acute incidence of thrombus formation within microvascular procedures

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