Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apoptotic machinery to induce tumor cell death. In this study, we set up protocols to purify functional mi...
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Autores principales: | Nelly Buron, Mathieu Porceddu, Magali Brabant, Diana Desgué, Cindy Racoeur, Myriam Lassalle, Christine Péchoux, Pierre Rustin, Etienne Jacotot, Annie Borgne-Sanchez |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/604e21aac70a44d090f8703181416ad2 |
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