THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES

Sodium sulfadiazine (SD-Na) is a drug extensively used for the treatment of certain infections caused by several kinds of microorganisms. Although SD-Na is widely used nowadays in therapeutics, the physicochemical information about their aqueous solutions is not complete at present. In this context,...

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Autores principales:	Daniel R. DELGADO, Fleming MARTÍNEZ R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2010
Materias:	Sodium sulfadiazine solubility cosolvency ethanol solution thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/605061398a694975bdbd5f4aa885dd29
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spelling	oai:doaj.org-article:605061398a694975bdbd5f4aa885dd292021-11-19T04:14:22ZTHERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES0121-40042145-2660https://doaj.org/article/605061398a694975bdbd5f4aa885dd292010-07-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/6344https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Sodium sulfadiazine (SD-Na) is a drug extensively used for the treatment of certain infections caused by several kinds of microorganisms. Although SD-Na is widely used nowadays in therapeutics, the physicochemical information about their aqueous solutions is not complete at present. In this context, by using the van’t Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for SD-Na in ethanol + water cosolvent mixtures, are evaluated from solubility data determined at temperatures from 278.15 to 308.15 K. The drug solubility is greatest in neat water and lowest in neat ethanol at all the temperatures studied. This behavior shows the negative cosolvent effect for this electrolyte drug in this solvent system. By means of enthalpy-entropy compensation analysis, non-linear vs. plot with positive slope from neat ethanol up to 0.60 in mass fraction of water and negative from this composition to neat water is obtained; accordingly to this result, it follows that the dissolution process of this drug in ethanol-rich is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear.Daniel R. DELGADOFleming MARTÍNEZ R.Universidad de AntioquiaarticleSodium sulfadiazinesolubilitycosolvencyethanolsolution thermodynamicsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 17, Iss 2 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sodium sulfadiazine solubility cosolvency ethanol solution thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Sodium sulfadiazine solubility cosolvency ethanol solution thermodynamics Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Daniel R. DELGADO Fleming MARTÍNEZ R. THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
description	Sodium sulfadiazine (SD-Na) is a drug extensively used for the treatment of certain infections caused by several kinds of microorganisms. Although SD-Na is widely used nowadays in therapeutics, the physicochemical information about their aqueous solutions is not complete at present. In this context, by using the van’t Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for SD-Na in ethanol + water cosolvent mixtures, are evaluated from solubility data determined at temperatures from 278.15 to 308.15 K. The drug solubility is greatest in neat water and lowest in neat ethanol at all the temperatures studied. This behavior shows the negative cosolvent effect for this electrolyte drug in this solvent system. By means of enthalpy-entropy compensation analysis, non-linear vs. plot with positive slope from neat ethanol up to 0.60 in mass fraction of water and negative from this composition to neat water is obtained; accordingly to this result, it follows that the dissolution process of this drug in ethanol-rich is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear.
format	article
author	Daniel R. DELGADO Fleming MARTÍNEZ R.
author_facet	Daniel R. DELGADO Fleming MARTÍNEZ R.
author_sort	Daniel R. DELGADO
title	THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
title_short	THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
title_full	THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
title_fullStr	THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
title_full_unstemmed	THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES
title_sort	thermodynamic study of the solubility of sodium sulfadiazine in some ethanol + water cosolvent mixtures
publisher	Universidad de Antioquia
publishDate	2010
url	https://doaj.org/article/605061398a694975bdbd5f4aa885dd29
work_keys_str_mv	AT danielrdelgado thermodynamicstudyofthesolubilityofsodiumsulfadiazineinsomeethanolwatercosolventmixtures AT flemingmartinezr thermodynamicstudyofthesolubilityofsodiumsulfadiazineinsomeethanolwatercosolventmixtures
_version_	1718420498623234048

THERMODYNAMIC STUDY OF THE SOLUBILITY OF SODIUM SULFADIAZINE IN SOME ETHANOL + WATER COSOLVENT MIXTURES

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