Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

Self-assembling protein nanoparticles (NPs) presenting BG505 envelope (Env) trimers can elicit tier 2 HIV-1-neutralizing antibody (NAb) responses more effectively than soluble trimers. In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and...

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Autores principales:	Sonu Kumar, Xiaohe Lin, Timothy Ngo, Benjamin Shapero, Cindy Sou, Joel D. Allen, Jeffrey Copps, Lei Zhang, Gabriel Ozorowski, Linling He, Max Crispin, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/60514c285c8841da8bbe265df10be289
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spelling	oai:doaj.org-article:60514c285c8841da8bbe265df10be2892021-11-03T21:15:03ZNeutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles2150-751110.1128/mBio.00429-21https://doaj.org/article/60514c285c8841da8bbe265df10be2892021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00429-21https://doaj.org/toc/2150-7511 Self-assembling protein nanoparticles (NPs) presenting BG505 envelope (Env) trimers can elicit tier 2 HIV-1-neutralizing antibody (NAb) responses more effectively than soluble trimers. In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and functional analyses, which revealed that potent mouse NAbs recognize the C3/V4 region and small NP-elicited rabbit NAbs primarily target known glycan holes on BG505 Env.Sonu KumarXiaohe LinTimothy NgoBenjamin ShaperoCindy SouJoel D. AllenJeffrey CoppsLei ZhangGabriel OzorowskiLinling HeMax CrispinAndrew B. WardIan A. WilsonJiang ZhuAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Sonu Kumar Xiaohe Lin Timothy Ngo Benjamin Shapero Cindy Sou Joel D. Allen Jeffrey Copps Lei Zhang Gabriel Ozorowski Linling He Max Crispin Andrew B. Ward Ian A. Wilson Jiang Zhu Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
description	Self-assembling protein nanoparticles (NPs) presenting BG505 envelope (Env) trimers can elicit tier 2 HIV-1-neutralizing antibody (NAb) responses more effectively than soluble trimers. In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and functional analyses, which revealed that potent mouse NAbs recognize the C3/V4 region and small NP-elicited rabbit NAbs primarily target known glycan holes on BG505 Env.
format	article
author	Sonu Kumar Xiaohe Lin Timothy Ngo Benjamin Shapero Cindy Sou Joel D. Allen Jeffrey Copps Lei Zhang Gabriel Ozorowski Linling He Max Crispin Andrew B. Ward Ian A. Wilson Jiang Zhu
author_facet	Sonu Kumar Xiaohe Lin Timothy Ngo Benjamin Shapero Cindy Sou Joel D. Allen Jeffrey Copps Lei Zhang Gabriel Ozorowski Linling He Max Crispin Andrew B. Ward Ian A. Wilson Jiang Zhu
author_sort	Sonu Kumar
title	Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
title_short	Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
title_full	Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
title_fullStr	Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
title_full_unstemmed	Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
title_sort	neutralizing antibodies induced by first-generation gp41-stabilized hiv-1 envelope trimers and nanoparticles
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/60514c285c8841da8bbe265df10be289
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Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

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