Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia

<h4>Background</h4> Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to t...

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Autores principales:	Osama M. Al-Amer, Atif Abdulwahab A. Oyouni, Mohammed Ali Alshehri, Abdulrahman Alasmari, Othman R. Alzahrani, Saad Ali S. Aljohani, Noura Alasmael, Abdulrahman Theyab, Mohammad Algahtani, Hadeel Al Sadoun, Khalaf F. Alsharif, Abdullah Hamad, Wed A. Abdali, Yousef MohammedRabaa Hawasawi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60515001fdf54112a4a9612e45da86bb
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spelling	oai:doaj.org-article:60515001fdf54112a4a9612e45da86bb2021-11-25T05:54:24ZAssociation of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia1932-6203https://doaj.org/article/60515001fdf54112a4a9612e45da86bb2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592490/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin. <h4>Aim</h4> The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia. <h4>Methods</h4> A cohort of 108 female university students aged 18–25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3–5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR. <h4>Results</h4> The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA. <h4>Conclusion</h4> Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.Osama M. Al-AmerAtif Abdulwahab A. OyouniMohammed Ali AlshehriAbdulrahman AlasmariOthman R. AlzahraniSaad Ali S. AljohaniNoura AlasmaelAbdulrahman TheyabMohammad AlgahtaniHadeel Al SadounKhalaf F. AlsharifAbdullah HamadWed A. AbdaliYousef MohammedRabaa HawasawiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Osama M. Al-Amer Atif Abdulwahab A. Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R. Alzahrani Saad Ali S. Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F. Alsharif Abdullah Hamad Wed A. Abdali Yousef MohammedRabaa Hawasawi Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
description	<h4>Background</h4> Globally, iron-deficiency anemia (IDA) remains a major health obstacle. This health condition has been identified in 47% of pre-school students (aged 0 to 5 years), 42% of pregnant females, and 30% of non-pregnant females (aged 15 to 50 years) worldwide according to the WHO. Environmental and genetic factors play a crucial role in the development of IDA; genetic testing has revealed the association of a number of polymorphisms with iron status and serum ferritin. <h4>Aim</h4> The current study aims to reveal the association of TMPRSS6 rs141312 and BMP2 rs235756 with the iron status of females in Saudi Arabia. <h4>Methods</h4> A cohort of 108 female university students aged 18–25 years was randomly selected to participate: 50 healthy and 58 classified as iron deficient. A 3–5 mL sample of blood was collected from each one and analyzed based on hematological and biochemical iron status followed by genotyping by PCR. <h4>Results</h4> The genotype distribution of TMPRSS6 rs141312 was 8% (TT), 88% (TC) and 4% (CC) in the healthy group compared with 3.45% (TT), 89.66% (TC) and 6.89% (CC) in the iron-deficient group (P = 0.492), an insignificant difference in the allelic distribution. The genotype distribution of BMP2 rs235756 was 8% (TT), 90% (TC) and 2% (CC) in the healthy group compared with 3.45% (TT), 82.76% (TC) and 13.79% (CC) in iron-deficient group (P = 0.050) and was significantly associated with decreased ferritin status (P = 0.050). In addition, TMPRSS6 rs141312 is significantly (P<0.001) associated with dominant genotypes (TC+CC) and increased risk of IDA while BMP2 rs235756 is significantly (P<0.026) associated with recessive homozygote CC genotypes and increased risk of IDA. <h4>Conclusion</h4> Our finding potentially helps in the early prediction of iron deficiency in females through the genetic testing.
format	article
author	Osama M. Al-Amer Atif Abdulwahab A. Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R. Alzahrani Saad Ali S. Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F. Alsharif Abdullah Hamad Wed A. Abdali Yousef MohammedRabaa Hawasawi
author_facet	Osama M. Al-Amer Atif Abdulwahab A. Oyouni Mohammed Ali Alshehri Abdulrahman Alasmari Othman R. Alzahrani Saad Ali S. Aljohani Noura Alasmael Abdulrahman Theyab Mohammad Algahtani Hadeel Al Sadoun Khalaf F. Alsharif Abdullah Hamad Wed A. Abdali Yousef MohammedRabaa Hawasawi
author_sort	Osama M. Al-Amer
title	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
title_short	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
title_full	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
title_fullStr	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
title_full_unstemmed	Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia
title_sort	association of snps within tmprss6 and bmp2 genes with iron deficiency status in saudi arabia
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/60515001fdf54112a4a9612e45da86bb
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Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia

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