Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bact...

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Autores principales:	Valerie Cortez, David F. Boyd, Jeremy Chase Crawford, Bridgett Sharp, Brandi Livingston, Hannah M. Rowe, Amy Davis, Ramzi Alsallaq, Camenzind G. Robinson, Peter Vogel, Jason W. Rosch, Elisa Margolis, Paul G. Thomas, Stacey Schultz-Cherry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6053f463514e437bb5ee437308a9eef9
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spelling	oai:doaj.org-article:6053f463514e437bb5ee437308a9eef92021-12-02T14:40:42ZAstrovirus infects actively secreting goblet cells and alters the gut mucus barrier10.1038/s41467-020-15999-y2041-1723https://doaj.org/article/6053f463514e437bb5ee437308a9eef92020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15999-yhttps://doaj.org/toc/2041-1723Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.Valerie CortezDavid F. BoydJeremy Chase CrawfordBridgett SharpBrandi LivingstonHannah M. RoweAmy DavisRamzi AlsallaqCamenzind G. RobinsonPeter VogelJason W. RoschElisa MargolisPaul G. ThomasStacey Schultz-CherryNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
description	Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.
format	article
author	Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry
author_facet	Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry
author_sort	Valerie Cortez
title	Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
title_short	Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
title_full	Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
title_fullStr	Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
title_full_unstemmed	Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
title_sort	astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6053f463514e437bb5ee437308a9eef9
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Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

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