Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that previous failure of CETP inhibitors are likely compoun...
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Nature Portfolio
2021
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oai:doaj.org-article:60544e33b7ec4a46bdebdd316f81bb1d2021-12-02T15:14:37ZCholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease10.1038/s41467-021-25703-32041-1723https://doaj.org/article/60544e33b7ec4a46bdebdd316f81bb1d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25703-3https://doaj.org/toc/2041-1723Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that previous failure of CETP inhibitors are likely compound and not drug target-related.Amand F. SchmidtNicholas B. HuntMaria Gordillo-MarañónPimphen CharoenFotios DrenosMika KivimakiDeborah A. LawlorClaudia GiambartolomeiOlia PapacostaNishi ChaturvediJoshua C. BisChristopher J. O’DonnellGoya WannametheeAndrew WongJackie F. PriceAlun D. HughesTom R. GauntNora FranceschiniDennis O. Mook-KanamoriMagdalena ZwierzynaReecha SofatAroon D. HingoraniChris FinanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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EN |
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Science Q |
| spellingShingle |
Science Q Amand F. Schmidt Nicholas B. Hunt Maria Gordillo-Marañón Pimphen Charoen Fotios Drenos Mika Kivimaki Deborah A. Lawlor Claudia Giambartolomei Olia Papacosta Nishi Chaturvedi Joshua C. Bis Christopher J. O’Donnell Goya Wannamethee Andrew Wong Jackie F. Price Alun D. Hughes Tom R. Gaunt Nora Franceschini Dennis O. Mook-Kanamori Magdalena Zwierzyna Reecha Sofat Aroon D. Hingorani Chris Finan Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| description |
Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that previous failure of CETP inhibitors are likely compound and not drug target-related. |
| format |
article |
| author |
Amand F. Schmidt Nicholas B. Hunt Maria Gordillo-Marañón Pimphen Charoen Fotios Drenos Mika Kivimaki Deborah A. Lawlor Claudia Giambartolomei Olia Papacosta Nishi Chaturvedi Joshua C. Bis Christopher J. O’Donnell Goya Wannamethee Andrew Wong Jackie F. Price Alun D. Hughes Tom R. Gaunt Nora Franceschini Dennis O. Mook-Kanamori Magdalena Zwierzyna Reecha Sofat Aroon D. Hingorani Chris Finan |
| author_facet |
Amand F. Schmidt Nicholas B. Hunt Maria Gordillo-Marañón Pimphen Charoen Fotios Drenos Mika Kivimaki Deborah A. Lawlor Claudia Giambartolomei Olia Papacosta Nishi Chaturvedi Joshua C. Bis Christopher J. O’Donnell Goya Wannamethee Andrew Wong Jackie F. Price Alun D. Hughes Tom R. Gaunt Nora Franceschini Dennis O. Mook-Kanamori Magdalena Zwierzyna Reecha Sofat Aroon D. Hingorani Chris Finan |
| author_sort |
Amand F. Schmidt |
| title |
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| title_short |
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| title_full |
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| title_fullStr |
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| title_full_unstemmed |
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease |
| title_sort |
cholesteryl ester transfer protein (cetp) as a drug target for cardiovascular disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/60544e33b7ec4a46bdebdd316f81bb1d |
| work_keys_str_mv |
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