PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women

Wojciech Łukasz Dragan,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Center for Behavior Genetic Research, Faculty of Psychology, University of Warsaw, Warsaw, 2Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, 3Faculty of Psychology, University of W...

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Autores principales:	Dragan WŁ, Czerski PM, Dragan M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	problematic alcohol use PAC1 gene AUDIT HPA axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/60547afddf4c41b8a152c281436f6e53
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spelling	oai:doaj.org-article:60547afddf4c41b8a152c281436f6e532021-12-02T02:24:33ZPAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women1178-2021https://doaj.org/article/60547afddf4c41b8a152c281436f6e532017-06-01T00:00:00Zhttps://www.dovepress.com/pac1-receptor-adcyap1r1-genotype-and-problematic-alcohol-use-in-a-samp-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wojciech Łukasz Dragan,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Center for Behavior Genetic Research, Faculty of Psychology, University of Warsaw, Warsaw, 2Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Recent studies revealed the role of the PAC1 (ADCYAP1R1) gene variability in vulnerability to posttraumatic stress disorder in women. Due to the relatively high comorbidity of posttraumatic stress disorder and substance use disorder, we hypothesized about possible associations between PAC1 gene and problematic alcohol use. Method: The sample studied consisted of 491 women aged 18–28 years (mean age =21.76 years; SD =1.83) and the Alcohol Use Disorders Identification Test was used to assess drinking problems. We successfully genotyped 17 single-nucleotide polymorphisms in the PAC1 gene. Results: Single locus analysis revealed a significant (after correction for multiple testing) association between intronic polymorphism rs2302475 and problematic alcohol use (P=0.00048; recessive model). This result was strengthened by the haplotype analysis (P=0.00379). Conclusion: Our results suggest that the PACAP/PAC1 signaling system is implicated in the development of problematic alcohol use in women. Keywords: problematic alcohol use, PAC1 gene, AUDIT, HPA axisDragan WŁCzerski PMDragan MDove Medical Pressarticleproblematic alcohol usePAC1 geneAUDITHPA axisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1483-1489 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	problematic alcohol use PAC1 gene AUDIT HPA axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	problematic alcohol use PAC1 gene AUDIT HPA axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dragan WŁ Czerski PM Dragan M PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
description	Wojciech Łukasz Dragan,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Center for Behavior Genetic Research, Faculty of Psychology, University of Warsaw, Warsaw, 2Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Recent studies revealed the role of the PAC1 (ADCYAP1R1) gene variability in vulnerability to posttraumatic stress disorder in women. Due to the relatively high comorbidity of posttraumatic stress disorder and substance use disorder, we hypothesized about possible associations between PAC1 gene and problematic alcohol use. Method: The sample studied consisted of 491 women aged 18–28 years (mean age =21.76 years; SD =1.83) and the Alcohol Use Disorders Identification Test was used to assess drinking problems. We successfully genotyped 17 single-nucleotide polymorphisms in the PAC1 gene. Results: Single locus analysis revealed a significant (after correction for multiple testing) association between intronic polymorphism rs2302475 and problematic alcohol use (P=0.00048; recessive model). This result was strengthened by the haplotype analysis (P=0.00379). Conclusion: Our results suggest that the PACAP/PAC1 signaling system is implicated in the development of problematic alcohol use in women. Keywords: problematic alcohol use, PAC1 gene, AUDIT, HPA axis
format	article
author	Dragan WŁ Czerski PM Dragan M
author_facet	Dragan WŁ Czerski PM Dragan M
author_sort	Dragan WŁ
title	PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
title_short	PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
title_full	PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
title_fullStr	PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
title_full_unstemmed	PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women
title_sort	pac1 receptor (adcyap1r1) genotype and problematic alcohol use in a sample of young women
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/60547afddf4c41b8a152c281436f6e53
work_keys_str_mv	AT draganwł pac1receptoradcyap1r1genotypeandproblematicalcoholuseinasampleofyoungwomen AT czerskipm pac1receptoradcyap1r1genotypeandproblematicalcoholuseinasampleofyoungwomen AT draganm pac1receptoradcyap1r1genotypeandproblematicalcoholuseinasampleofyoungwomen
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PAC1 receptor (ADCYAP1R1) genotype and problematic alcohol use in a sample of young women

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