Local and network-level dysregulation of error processing is associated with binge drinking

Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inabili...

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Autores principales:	Austin B. Alderson Myers, Donatello Arienzo, Sean M. Molnar, Ksenija Marinkovic
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Error processing Cognitive control Binge drinking Go/NoGo Functional magnetic resonance imaging Functional connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6054989297924cde92259243d81449c3
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spelling	oai:doaj.org-article:6054989297924cde92259243d81449c32021-11-10T04:25:35ZLocal and network-level dysregulation of error processing is associated with binge drinking2213-158210.1016/j.nicl.2021.102879https://doaj.org/article/6054989297924cde92259243d81449c32021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003235https://doaj.org/toc/2213-1582Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inability to refrain from excessive alcohol intake. As a facet of cognitive control, error processing allows for flexible modification of behavior to optimize future outcomes. It is highly relevant to addiction research, as a failure to inhibit excessive drinking results in relapses, which is a hallmark of alcohol use disorder. However, research on local and system-level neural underpinnings of inhibition failures as a function of binge drinking is limited. To address these gaps, functional magnetic resonance imaging (fMRI) was used to examine local changes and interregional functional connectivity during response inhibition errors on a Go/NoGo task. Young adult binge drinkers (BDs) performed equally well as light drinkers (LDs), a group of demographically matched individuals who drink regularly but in low-risk patterns. In contrast, BDs exhibited greater fMRI activity to inhibition errors contrasted with correct NoGo trials in the rostral anterior (rACC) and posterior cingulate cortices (PCC), as well as right middle frontal gyrus (R-MFG). Furthermore, BDs showed increased connectivity between the rACC and right lateral prefrontal cortex, in addition to greater connectivity between the R-MFG and the left ventrolateral and superior frontal cortices. Imaging indices were positively correlated only with alcohol-related measures, but not with those related to moods, disposition, or cognitive capacity. Taken together, greater error-related activity and expanded functional connectivity among prefrontal regions may serve a compensatory role to maintain efficiency of inhibitory control. Aligned with prominent models of addiction, these findings accentuate the importance of top-down control in maintaining low-risk drinking levels. They provide insight into potentially early signs of deteriorating cognitive control functions in BDs and may help guide intervention strategies aimed at preventing excessive drinking habits.Austin B. Alderson MyersDonatello ArienzoSean M. MolnarKsenija MarinkovicElsevierarticleError processingCognitive controlBinge drinkingGo/NoGoFunctional magnetic resonance imagingFunctional connectivityComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102879- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Error processing Cognitive control Binge drinking Go/NoGo Functional magnetic resonance imaging Functional connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Error processing Cognitive control Binge drinking Go/NoGo Functional magnetic resonance imaging Functional connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Austin B. Alderson Myers Donatello Arienzo Sean M. Molnar Ksenija Marinkovic Local and network-level dysregulation of error processing is associated with binge drinking
description	Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inability to refrain from excessive alcohol intake. As a facet of cognitive control, error processing allows for flexible modification of behavior to optimize future outcomes. It is highly relevant to addiction research, as a failure to inhibit excessive drinking results in relapses, which is a hallmark of alcohol use disorder. However, research on local and system-level neural underpinnings of inhibition failures as a function of binge drinking is limited. To address these gaps, functional magnetic resonance imaging (fMRI) was used to examine local changes and interregional functional connectivity during response inhibition errors on a Go/NoGo task. Young adult binge drinkers (BDs) performed equally well as light drinkers (LDs), a group of demographically matched individuals who drink regularly but in low-risk patterns. In contrast, BDs exhibited greater fMRI activity to inhibition errors contrasted with correct NoGo trials in the rostral anterior (rACC) and posterior cingulate cortices (PCC), as well as right middle frontal gyrus (R-MFG). Furthermore, BDs showed increased connectivity between the rACC and right lateral prefrontal cortex, in addition to greater connectivity between the R-MFG and the left ventrolateral and superior frontal cortices. Imaging indices were positively correlated only with alcohol-related measures, but not with those related to moods, disposition, or cognitive capacity. Taken together, greater error-related activity and expanded functional connectivity among prefrontal regions may serve a compensatory role to maintain efficiency of inhibitory control. Aligned with prominent models of addiction, these findings accentuate the importance of top-down control in maintaining low-risk drinking levels. They provide insight into potentially early signs of deteriorating cognitive control functions in BDs and may help guide intervention strategies aimed at preventing excessive drinking habits.
format	article
author	Austin B. Alderson Myers Donatello Arienzo Sean M. Molnar Ksenija Marinkovic
author_facet	Austin B. Alderson Myers Donatello Arienzo Sean M. Molnar Ksenija Marinkovic
author_sort	Austin B. Alderson Myers
title	Local and network-level dysregulation of error processing is associated with binge drinking
title_short	Local and network-level dysregulation of error processing is associated with binge drinking
title_full	Local and network-level dysregulation of error processing is associated with binge drinking
title_fullStr	Local and network-level dysregulation of error processing is associated with binge drinking
title_full_unstemmed	Local and network-level dysregulation of error processing is associated with binge drinking
title_sort	local and network-level dysregulation of error processing is associated with binge drinking
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6054989297924cde92259243d81449c3
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Local and network-level dysregulation of error processing is associated with binge drinking

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