Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile

Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two models show similar bulk transcriptomic profiles, b...

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Autores principales:	Daniel Shiloh Malawsky, Seth J. Weir, Jennifer Karin Ocasio, Benjamin Babcock, Taylor Dismuke, Abigail H. Cleveland, Andrew M. Donson, Rajeev Vibhakar, Kirk Wilhelmsen, Timothy R. Gershon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
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spelling	oai:doaj.org-article:605864249f4542d69b3f957f5ac481cd2021-12-02T14:59:12ZCryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile10.1038/s42003-021-02099-w2399-3642https://doaj.org/article/605864249f4542d69b3f957f5ac481cd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02099-whttps://doaj.org/toc/2399-3642Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two models show similar bulk transcriptomic profiles, but contain different fractions of tumor stem cells and different myeloid populations, and demonstrate different therapeutic responses.Daniel Shiloh MalawskySeth J. WeirJennifer Karin OcasioBenjamin BabcockTaylor DismukeAbigail H. ClevelandAndrew M. DonsonRajeev VibhakarKirk WilhelmsenTimothy R. GershonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniel Shiloh Malawsky Seth J. Weir Jennifer Karin Ocasio Benjamin Babcock Taylor Dismuke Abigail H. Cleveland Andrew M. Donson Rajeev Vibhakar Kirk Wilhelmsen Timothy R. Gershon Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
description	Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two models show similar bulk transcriptomic profiles, but contain different fractions of tumor stem cells and different myeloid populations, and demonstrate different therapeutic responses.
format	article
author	Daniel Shiloh Malawsky Seth J. Weir Jennifer Karin Ocasio Benjamin Babcock Taylor Dismuke Abigail H. Cleveland Andrew M. Donson Rajeev Vibhakar Kirk Wilhelmsen Timothy R. Gershon
author_facet	Daniel Shiloh Malawsky Seth J. Weir Jennifer Karin Ocasio Benjamin Babcock Taylor Dismuke Abigail H. Cleveland Andrew M. Donson Rajeev Vibhakar Kirk Wilhelmsen Timothy R. Gershon
author_sort	Daniel Shiloh Malawsky
title	Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
title_short	Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
title_full	Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
title_fullStr	Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
title_full_unstemmed	Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
title_sort	cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
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Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile

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