Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile

Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two models show similar bulk transcriptomic profiles, b...

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Auteurs principaux: Daniel Shiloh Malawsky, Seth J. Weir, Jennifer Karin Ocasio, Benjamin Babcock, Taylor Dismuke, Abigail H. Cleveland, Andrew M. Donson, Rajeev Vibhakar, Kirk Wilhelmsen, Timothy R. Gershon
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
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