Iron Homeostasis Disorder and Alzheimer’s Disease

Iron is an essential trace metal for almost all organisms, including human; however, oxidative stress can easily be caused when iron is in excess, producing toxicity to the human body due to its capability to be both an electron donor and an electron acceptor. Although there is a strict regulation m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Peng, Xuejiao Chang, Minglin Lang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease iron homeostasis disorder iron homeostasis regulators β-amyloid tau APP Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6058674f614d4d88b2069ca014dd6ce6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6058674f614d4d88b2069ca014dd6ce6
record_format	dspace
spelling	oai:doaj.org-article:6058674f614d4d88b2069ca014dd6ce62021-11-25T17:56:43ZIron Homeostasis Disorder and Alzheimer’s Disease10.3390/ijms2222124421422-00671661-6596https://doaj.org/article/6058674f614d4d88b2069ca014dd6ce62021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12442https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Iron is an essential trace metal for almost all organisms, including human; however, oxidative stress can easily be caused when iron is in excess, producing toxicity to the human body due to its capability to be both an electron donor and an electron acceptor. Although there is a strict regulation mechanism for iron homeostasis in the human body and brain, it is usually inevitably disturbed by genetic and environmental factors, or disordered with aging, which leads to iron metabolism diseases, including many neurodegenerative diseases such as Alzheimer’s disease (AD). AD is one of the most common degenerative diseases of the central nervous system (CNS) threatening human health. However, the precise pathogenesis of AD is still unclear, which seriously restricts the design of interventions and treatment drugs based on the pathogenesis of AD. Many studies have observed abnormal iron accumulation in different regions of the AD brain, resulting in cognitive, memory, motor and other nerve damages. Understanding the metabolic balance mechanism of iron in the brain is crucial for the treatment of AD, which would provide new cures for the disease. This paper reviews the recent progress in the relationship between iron and AD from the aspects of iron absorption in intestinal cells, storage and regulation of iron in cells and organs, especially for the regulation of iron homeostasis in the human brain and prospects the future directions for AD treatments.Yu PengXuejiao ChangMinglin LangMDPI AGarticleAlzheimer’s diseaseiron homeostasis disorderiron homeostasis regulatorsβ-amyloidtauAPPBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12442, p 12442 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease iron homeostasis disorder iron homeostasis regulators β-amyloid tau APP Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Alzheimer’s disease iron homeostasis disorder iron homeostasis regulators β-amyloid tau APP Biology (General) QH301-705.5 Chemistry QD1-999 Yu Peng Xuejiao Chang Minglin Lang Iron Homeostasis Disorder and Alzheimer’s Disease
description	Iron is an essential trace metal for almost all organisms, including human; however, oxidative stress can easily be caused when iron is in excess, producing toxicity to the human body due to its capability to be both an electron donor and an electron acceptor. Although there is a strict regulation mechanism for iron homeostasis in the human body and brain, it is usually inevitably disturbed by genetic and environmental factors, or disordered with aging, which leads to iron metabolism diseases, including many neurodegenerative diseases such as Alzheimer’s disease (AD). AD is one of the most common degenerative diseases of the central nervous system (CNS) threatening human health. However, the precise pathogenesis of AD is still unclear, which seriously restricts the design of interventions and treatment drugs based on the pathogenesis of AD. Many studies have observed abnormal iron accumulation in different regions of the AD brain, resulting in cognitive, memory, motor and other nerve damages. Understanding the metabolic balance mechanism of iron in the brain is crucial for the treatment of AD, which would provide new cures for the disease. This paper reviews the recent progress in the relationship between iron and AD from the aspects of iron absorption in intestinal cells, storage and regulation of iron in cells and organs, especially for the regulation of iron homeostasis in the human brain and prospects the future directions for AD treatments.
format	article
author	Yu Peng Xuejiao Chang Minglin Lang
author_facet	Yu Peng Xuejiao Chang Minglin Lang
author_sort	Yu Peng
title	Iron Homeostasis Disorder and Alzheimer’s Disease
title_short	Iron Homeostasis Disorder and Alzheimer’s Disease
title_full	Iron Homeostasis Disorder and Alzheimer’s Disease
title_fullStr	Iron Homeostasis Disorder and Alzheimer’s Disease
title_full_unstemmed	Iron Homeostasis Disorder and Alzheimer’s Disease
title_sort	iron homeostasis disorder and alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6058674f614d4d88b2069ca014dd6ce6
work_keys_str_mv	AT yupeng ironhomeostasisdisorderandalzheimersdisease AT xuejiaochang ironhomeostasisdisorderandalzheimersdisease AT minglinlang ironhomeostasisdisorderandalzheimersdisease
_version_	1718411805107159040

Iron Homeostasis Disorder and Alzheimer’s Disease

Ejemplares similares