Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ju-Yong Park, Seon-Myeong Kim, Jung-Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	canine atopic dermatitis (CAD) skin microbiome skin barrier function phototherapy (PTT) excimer light Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/605e52ee1b72468092637cd5fbce7d66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:605e52ee1b72468092637cd5fbce7d66
record_format	dspace
spelling	oai:doaj.org-article:605e52ee1b72468092637cd5fbce7d662021-12-03T05:10:04ZEfficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis2297-176910.3389/fvets.2021.762961https://doaj.org/article/605e52ee1b72468092637cd5fbce7d662021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.762961/fullhttps://doaj.org/toc/2297-1769The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.Ju-Yong ParkSeon-Myeong KimJung-Hyun KimFrontiers Media S.A.articlecanine atopic dermatitis (CAD)skin microbiomeskin barrier functionphototherapy (PTT)excimer lightVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine atopic dermatitis (CAD) skin microbiome skin barrier function phototherapy (PTT) excimer light Veterinary medicine SF600-1100
spellingShingle	canine atopic dermatitis (CAD) skin microbiome skin barrier function phototherapy (PTT) excimer light Veterinary medicine SF600-1100 Ju-Yong Park Seon-Myeong Kim Jung-Hyun Kim Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
description	The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.
format	article
author	Ju-Yong Park Seon-Myeong Kim Jung-Hyun Kim
author_facet	Ju-Yong Park Seon-Myeong Kim Jung-Hyun Kim
author_sort	Ju-Yong Park
title	Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
title_short	Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
title_full	Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
title_fullStr	Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
title_full_unstemmed	Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis
title_sort	efficacy of phototherapy with 308-nm excimer light for skin microbiome dysbiosis and skin barrier dysfunction in canine atopic dermatitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/605e52ee1b72468092637cd5fbce7d66
work_keys_str_mv	AT juyongpark efficacyofphototherapywith308nmexcimerlightforskinmicrobiomedysbiosisandskinbarrierdysfunctionincanineatopicdermatitis AT seonmyeongkim efficacyofphototherapywith308nmexcimerlightforskinmicrobiomedysbiosisandskinbarrierdysfunctionincanineatopicdermatitis AT junghyunkim efficacyofphototherapywith308nmexcimerlightforskinmicrobiomedysbiosisandskinbarrierdysfunctionincanineatopicdermatitis
_version_	1718373933185499136

Efficacy of Phototherapy With 308-nm Excimer Light for Skin Microbiome Dysbiosis and Skin Barrier Dysfunction in Canine Atopic Dermatitis

Ejemplares similares