Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway

A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110α in alcoholic liver disease (ALD). Methyl ferulic acid (MFA), a bioactive ingredient in Securidaca inappendiculata Hassk rhizomes, exhi...

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Autores principales:	Yan Zhang, Jun Lu, Yu-juan Zhong, Cheng-fang Yang, Li Chen, Dan Wu, Meng-wei Song, Lin Shi, Zu-heng Ma, Li Li, Yong-wen Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Methyl ferulic acid MiR-378b Alcoholic liver disease Insulin resistance Insulin receptor P110α Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/605f72c9dbdb40248105e1a9d8be49df
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spelling	oai:doaj.org-article:605f72c9dbdb40248105e1a9d8be49df2021-11-28T04:28:23ZMethyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway0753-332210.1016/j.biopha.2021.112462https://doaj.org/article/605f72c9dbdb40248105e1a9d8be49df2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012488https://doaj.org/toc/0753-3322A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110α in alcoholic liver disease (ALD). Methyl ferulic acid (MFA), a bioactive ingredient in Securidaca inappendiculata Hassk rhizomes, exhibits multiple pharmacological activities. It has been reported that MFA ameliorates insulin resistance in ALD, whereas the underlying molecular mechanism remains unclear. The objective of study was to evaluate the influence of MFA on insulin sensitivity in ethanol-induced L-02 cells as well as alcohol-fed mice and illuminate the function of miR-378b-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway in system. MFA was found to remarkably down-regulate miR-378b level and increase IR and p110α expressions. Furthermore, the effect of MFA on modulating miR-378b/PI3K-AKT pathway to enhance insulin sensitivity was corroborated by overexpressing and inhibiting miR-378b. Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110α and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance.Yan ZhangJun LuYu-juan ZhongCheng-fang YangLi ChenDan WuMeng-wei SongLin ShiZu-heng MaLi LiYong-wen LiElsevierarticleMethyl ferulic acidMiR-378bAlcoholic liver diseaseInsulin resistanceInsulin receptorP110αTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112462- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Methyl ferulic acid MiR-378b Alcoholic liver disease Insulin resistance Insulin receptor P110α Therapeutics. Pharmacology RM1-950
spellingShingle	Methyl ferulic acid MiR-378b Alcoholic liver disease Insulin resistance Insulin receptor P110α Therapeutics. Pharmacology RM1-950 Yan Zhang Jun Lu Yu-juan Zhong Cheng-fang Yang Li Chen Dan Wu Meng-wei Song Lin Shi Zu-heng Ma Li Li Yong-wen Li Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
description	A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110α in alcoholic liver disease (ALD). Methyl ferulic acid (MFA), a bioactive ingredient in Securidaca inappendiculata Hassk rhizomes, exhibits multiple pharmacological activities. It has been reported that MFA ameliorates insulin resistance in ALD, whereas the underlying molecular mechanism remains unclear. The objective of study was to evaluate the influence of MFA on insulin sensitivity in ethanol-induced L-02 cells as well as alcohol-fed mice and illuminate the function of miR-378b-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway in system. MFA was found to remarkably down-regulate miR-378b level and increase IR and p110α expressions. Furthermore, the effect of MFA on modulating miR-378b/PI3K-AKT pathway to enhance insulin sensitivity was corroborated by overexpressing and inhibiting miR-378b. Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110α and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance.
format	article
author	Yan Zhang Jun Lu Yu-juan Zhong Cheng-fang Yang Li Chen Dan Wu Meng-wei Song Lin Shi Zu-heng Ma Li Li Yong-wen Li
author_facet	Yan Zhang Jun Lu Yu-juan Zhong Cheng-fang Yang Li Chen Dan Wu Meng-wei Song Lin Shi Zu-heng Ma Li Li Yong-wen Li
author_sort	Yan Zhang
title	Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
title_short	Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
title_full	Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
title_fullStr	Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
title_full_unstemmed	Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
title_sort	methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via mir-378b-mediated activation of pi3k-akt pathway
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/605f72c9dbdb40248105e1a9d8be49df
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Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway

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