Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

ABSTRACT The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in bacterial physiology, with roles that range from supporting protein synthesis to signaling and fine-tuning the adaptation to amino acid starvation. In some pathogenic bacteria, the adaptation to amin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julienne C. Kaiser, David E. Heinrichs
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Listeria Staphylococcus branched-chain amino acids nutrient starvation response regulation virulence Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/605f8ea543714786bc7218473a6b5617
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:605f8ea543714786bc7218473a6b5617
record_format	dspace
spelling	oai:doaj.org-article:605f8ea543714786bc7218473a6b56172021-11-15T15:58:21ZBranching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation10.1128/mBio.01188-182150-7511https://doaj.org/article/605f8ea543714786bc7218473a6b56172018-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01188-18https://doaj.org/toc/2150-7511ABSTRACT The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in bacterial physiology, with roles that range from supporting protein synthesis to signaling and fine-tuning the adaptation to amino acid starvation. In some pathogenic bacteria, the adaptation to amino acid starvation includes induction of virulence gene expression: thus, BCAAs support not only proliferation during infection, but also the evasion of host defenses. A body of research has accumulated over the years to describe the multifaceted physiological roles of BCAAs and the mechanisms bacteria use to maintain their intracellular levels. More recent studies have focused on understanding how fluctuations in their intracellular levels impact global regulatory pathways that coordinate the adaptation to nutrient limitation, especially in pathogenic bacteria. In this minireview, we discuss how these studies have refined the individual roles of BCAAs, shed light on how BCAA auxotrophy might promote higher sensitivity to exogenous BCAA levels, and revealed pathogen-specific responses to BCAA deprivation. These advancements improve our understanding of how bacteria meet their nutritional requirements for growth while simultaneously remaining responsive to changes in environmental nutrient availability to promote their survival in a range of environments.Julienne C. KaiserDavid E. HeinrichsAmerican Society for MicrobiologyarticleListeriaStaphylococcusbranched-chain amino acidsnutrient starvation responseregulationvirulenceMicrobiologyQR1-502ENmBio, Vol 9, Iss 5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Listeria Staphylococcus branched-chain amino acids nutrient starvation response regulation virulence Microbiology QR1-502
spellingShingle	Listeria Staphylococcus branched-chain amino acids nutrient starvation response regulation virulence Microbiology QR1-502 Julienne C. Kaiser David E. Heinrichs Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
description	ABSTRACT The branched-chain amino acids (BCAAs [Ile, Leu, and Val]) represent important nutrients in bacterial physiology, with roles that range from supporting protein synthesis to signaling and fine-tuning the adaptation to amino acid starvation. In some pathogenic bacteria, the adaptation to amino acid starvation includes induction of virulence gene expression: thus, BCAAs support not only proliferation during infection, but also the evasion of host defenses. A body of research has accumulated over the years to describe the multifaceted physiological roles of BCAAs and the mechanisms bacteria use to maintain their intracellular levels. More recent studies have focused on understanding how fluctuations in their intracellular levels impact global regulatory pathways that coordinate the adaptation to nutrient limitation, especially in pathogenic bacteria. In this minireview, we discuss how these studies have refined the individual roles of BCAAs, shed light on how BCAA auxotrophy might promote higher sensitivity to exogenous BCAA levels, and revealed pathogen-specific responses to BCAA deprivation. These advancements improve our understanding of how bacteria meet their nutritional requirements for growth while simultaneously remaining responsive to changes in environmental nutrient availability to promote their survival in a range of environments.
format	article
author	Julienne C. Kaiser David E. Heinrichs
author_facet	Julienne C. Kaiser David E. Heinrichs
author_sort	Julienne C. Kaiser
title	Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
title_short	Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
title_full	Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
title_fullStr	Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
title_full_unstemmed	Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation
title_sort	branching out: alterations in bacterial physiology and virulence due to branched-chain amino acid deprivation
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/605f8ea543714786bc7218473a6b5617
work_keys_str_mv	AT julienneckaiser branchingoutalterationsinbacterialphysiologyandvirulenceduetobranchedchainaminoaciddeprivation AT davideheinrichs branchingoutalterationsinbacterialphysiologyandvirulenceduetobranchedchainaminoaciddeprivation
_version_	1718427031509663744

Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation

Ejemplares similares