Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea

Abstract This study is to elucidate the associations between female reproductive factors and pterygium. A total of 1,339,969 postmenopausal women in a retrospective cohort of Korean National Health Insurance Service data on ages 40 and above in 2009 was included. Cox proportional hazards regression...

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Autores principales:	Eunhae Shin, Dong Hui Lim, Tae-Young Chung, Gyule Han, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Dong Wook Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6060368026df44b4a6c7e709ea9344f9
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spelling	oai:doaj.org-article:6060368026df44b4a6c7e709ea9344f92021-12-02T17:23:50ZReproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea10.1038/s41598-021-91968-92045-2322https://doaj.org/article/6060368026df44b4a6c7e709ea9344f92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91968-9https://doaj.org/toc/2045-2322Abstract This study is to elucidate the associations between female reproductive factors and pterygium. A total of 1,339,969 postmenopausal women in a retrospective cohort of Korean National Health Insurance Service data on ages 40 and above in 2009 was included. Cox proportional hazards regression was conducted to assess the hazard ratio (HR) for pterygium according to reproductive factors. Late menarche, early menopause, short reproductive period, increasing parity (≥ 2 children), breastfeeding (≥ 6 months), and no use of hormone replacement therapy (HRT) or oral contraceptive (OC) were significantly associated with risk of pterygium. In multivariate analysis, the HR for pterygium was 1.764 (95% confidence interval [CI], 1.529–2.035) for menarche age ≥ 17 years (reference: menarche age < 12 years). The HR of menopause age ≥ 55 years was 0.782 (95% CI, 0.724–0.845) (reference: menopause age < 40 years). The HR of parity ≥ 2 was 1.261 (95% CI, 1.148–1.385) (reference: nulliparity). The HR of breastfeeding ≥ 1 year was 1.663 (95% CI, 1.564–1.768) (reference: no breastfeeding). The HRs of HRT and OC use for any length of time were lower than those for the non-user groups (reference). Reproductive factors that increase estrogen exposure have protective effects against pterygium in females.Eunhae ShinDong Hui LimTae-Young ChungGyule HanJung Eun YooKeun Hye JeonKyungdo HanDong Wook ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eunhae Shin Dong Hui Lim Tae-Young Chung Gyule Han Jung Eun Yoo Keun Hye Jeon Kyungdo Han Dong Wook Shin Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
description	Abstract This study is to elucidate the associations between female reproductive factors and pterygium. A total of 1,339,969 postmenopausal women in a retrospective cohort of Korean National Health Insurance Service data on ages 40 and above in 2009 was included. Cox proportional hazards regression was conducted to assess the hazard ratio (HR) for pterygium according to reproductive factors. Late menarche, early menopause, short reproductive period, increasing parity (≥ 2 children), breastfeeding (≥ 6 months), and no use of hormone replacement therapy (HRT) or oral contraceptive (OC) were significantly associated with risk of pterygium. In multivariate analysis, the HR for pterygium was 1.764 (95% confidence interval [CI], 1.529–2.035) for menarche age ≥ 17 years (reference: menarche age < 12 years). The HR of menopause age ≥ 55 years was 0.782 (95% CI, 0.724–0.845) (reference: menopause age < 40 years). The HR of parity ≥ 2 was 1.261 (95% CI, 1.148–1.385) (reference: nulliparity). The HR of breastfeeding ≥ 1 year was 1.663 (95% CI, 1.564–1.768) (reference: no breastfeeding). The HRs of HRT and OC use for any length of time were lower than those for the non-user groups (reference). Reproductive factors that increase estrogen exposure have protective effects against pterygium in females.
format	article
author	Eunhae Shin Dong Hui Lim Tae-Young Chung Gyule Han Jung Eun Yoo Keun Hye Jeon Kyungdo Han Dong Wook Shin
author_facet	Eunhae Shin Dong Hui Lim Tae-Young Chung Gyule Han Jung Eun Yoo Keun Hye Jeon Kyungdo Han Dong Wook Shin
author_sort	Eunhae Shin
title	Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
title_short	Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
title_full	Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
title_fullStr	Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
title_full_unstemmed	Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
title_sort	reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the republic of korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6060368026df44b4a6c7e709ea9344f9
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Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea

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