Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients...

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Autores principales:	Zhuo Yafen, Ling Lin, Sun Zhichun, Huang Wensen, Hong Zhenzhen, Zhang Yaping, Peng Xuefeng, Liu Xiaoyu, Yuan Weilan, Xu Wang-Yang, Zhang Yi
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	25(oh)d level vitamin d urinary iodine concentration type 2 diabetes mellitus t2dm risk a prediction model Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6060c0e3314b45ed86c95e3d25cf5f83
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spelling	oai:doaj.org-article:6060c0e3314b45ed86c95e3d25cf5f832021-12-05T14:10:40ZVitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China2391-541210.1515/biol-2021-0019https://doaj.org/article/6060c0e3314b45ed86c95e3d25cf5f832021-02-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0019https://doaj.org/toc/2391-5412The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.Zhuo YafenLing LinSun ZhichunHuang WensenHong ZhenzhenZhang YapingPeng XuefengLiu XiaoyuYuan WeilanXu Wang-YangZhang YiDe Gruyterarticle25(oh)d levelvitamin durinary iodine concentrationtype 2 diabetes mellitust2dm riska prediction modelBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 150-159 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	25(oh)d level vitamin d urinary iodine concentration type 2 diabetes mellitus t2dm risk a prediction model Biology (General) QH301-705.5
spellingShingle	25(oh)d level vitamin d urinary iodine concentration type 2 diabetes mellitus t2dm risk a prediction model Biology (General) QH301-705.5 Zhuo Yafen Ling Lin Sun Zhichun Huang Wensen Hong Zhenzhen Zhang Yaping Peng Xuefeng Liu Xiaoyu Yuan Weilan Xu Wang-Yang Zhang Yi Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
description	The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.
format	article
author	Zhuo Yafen Ling Lin Sun Zhichun Huang Wensen Hong Zhenzhen Zhang Yaping Peng Xuefeng Liu Xiaoyu Yuan Weilan Xu Wang-Yang Zhang Yi
author_facet	Zhuo Yafen Ling Lin Sun Zhichun Huang Wensen Hong Zhenzhen Zhang Yaping Peng Xuefeng Liu Xiaoyu Yuan Weilan Xu Wang-Yang Zhang Yi
author_sort	Zhuo Yafen
title	Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_short	Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_full	Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_fullStr	Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_full_unstemmed	Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_sort	vitamin d and iodine status was associated with the risk and complication of type 2 diabetes mellitus in china
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/6060c0e3314b45ed86c95e3d25cf5f83
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Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

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