The Role of Exercise and Mitochondrial Biogenesis in Aging Process

Aging can be defined as the progressive accumulation of changes with time associated with increasing vulnerability to disease and death which accompanies advancing age. The time related changes are attributed to the aging process (Harman, 1981). There are growing evidences that a number of the detri...

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Autor principal:	Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/60621772c7c247908593fa2e2fd5dfb8
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spelling	oai:doaj.org-article:60621772c7c247908593fa2e2fd5dfb82021-11-25T13:16:01ZThe Role of Exercise and Mitochondrial Biogenesis in Aging Process2085-15452339-093X10.26532/sainsmed.v9i1.4871https://doaj.org/article/60621772c7c247908593fa2e2fd5dfb82018-06-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/4871https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XAging can be defined as the progressive accumulation of changes with time associated with increasing vulnerability to disease and death which accompanies advancing age. The time related changes are attributed to the aging process (Harman, 1981). There are growing evidences that a number of the detrimental free radicals reactions are continuously occur throughout the cells of the body constituting the prominent contributor to aging process (Harman, 1981). This theory was extended to mitochondrial theory of aging, suggesting that mitochondria as the main source and target of reactive oxygen species (ROS) produced in association with aging processes and degenerative diseases (Payne and Chinnery, 2015). Mitochondria has a pivotal roles in multiple cellular processes such as oxidative phosphorylation (OXPHOS), apoptosis, b-oxidation of fatty acids, steroid biosynthesis, calcium homeostasis, intermediary metabolism, and cell signaling (Yin and Cadenas, 2015). Recent studies indicated that oxidative damage due to accumulation of ROS result from mitochondria production were associated with multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging (Cedikova et al., 2016).Taufiqurrachman NasihunUniversitas Sultan Agung SemarangarticleMedicine (General)R5-920ENSains Medika, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Taufiqurrachman Nasihun The Role of Exercise and Mitochondrial Biogenesis in Aging Process
description	Aging can be defined as the progressive accumulation of changes with time associated with increasing vulnerability to disease and death which accompanies advancing age. The time related changes are attributed to the aging process (Harman, 1981). There are growing evidences that a number of the detrimental free radicals reactions are continuously occur throughout the cells of the body constituting the prominent contributor to aging process (Harman, 1981). This theory was extended to mitochondrial theory of aging, suggesting that mitochondria as the main source and target of reactive oxygen species (ROS) produced in association with aging processes and degenerative diseases (Payne and Chinnery, 2015). Mitochondria has a pivotal roles in multiple cellular processes such as oxidative phosphorylation (OXPHOS), apoptosis, b-oxidation of fatty acids, steroid biosynthesis, calcium homeostasis, intermediary metabolism, and cell signaling (Yin and Cadenas, 2015). Recent studies indicated that oxidative damage due to accumulation of ROS result from mitochondria production were associated with multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging (Cedikova et al., 2016).
format	article
author	Taufiqurrachman Nasihun
author_facet	Taufiqurrachman Nasihun
author_sort	Taufiqurrachman Nasihun
title	The Role of Exercise and Mitochondrial Biogenesis in Aging Process
title_short	The Role of Exercise and Mitochondrial Biogenesis in Aging Process
title_full	The Role of Exercise and Mitochondrial Biogenesis in Aging Process
title_fullStr	The Role of Exercise and Mitochondrial Biogenesis in Aging Process
title_full_unstemmed	The Role of Exercise and Mitochondrial Biogenesis in Aging Process
title_sort	role of exercise and mitochondrial biogenesis in aging process
publisher	Universitas Sultan Agung Semarang
publishDate	2018
url	https://doaj.org/article/60621772c7c247908593fa2e2fd5dfb8
work_keys_str_mv	AT taufiqurrachmannasihun theroleofexerciseandmitochondrialbiogenesisinagingprocess AT taufiqurrachmannasihun roleofexerciseandmitochondrialbiogenesisinagingprocess
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The Role of Exercise and Mitochondrial Biogenesis in Aging Process

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