Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

In multiple myeloma, malignant cells expand within bone marrow. Here, the authors use multi-region sequencing in patient samples to analyse spatial clonal architecture and heterogeneity, providing novel insight into multiple myeloma progression and evolution.

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Autores principales:	L. Rasche, S. S. Chavan, O. W. Stephens, P. H. Patel, R. Tytarenko, C. Ashby, M. Bauer, C. Stein, S. Deshpande, C. Wardell, T. Buzder, G. Molnar, M. Zangari, F. van Rhee, S. Thanendrarajan, C. Schinke, J. Epstein, F. E. Davies, B. A. Walker, T. Meissner, B. Barlogie, G. J. Morgan, N. Weinhold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/606531925289417ab3689547176c20ed
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spelling	oai:doaj.org-article:606531925289417ab3689547176c20ed2021-12-02T10:48:28ZSpatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing10.1038/s41467-017-00296-y2041-1723https://doaj.org/article/606531925289417ab3689547176c20ed2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00296-yhttps://doaj.org/toc/2041-1723In multiple myeloma, malignant cells expand within bone marrow. Here, the authors use multi-region sequencing in patient samples to analyse spatial clonal architecture and heterogeneity, providing novel insight into multiple myeloma progression and evolution.L. RascheS. S. ChavanO. W. StephensP. H. PatelR. TytarenkoC. AshbyM. BauerC. SteinS. DeshpandeC. WardellT. BuzderG. MolnarM. ZangariF. van RheeS. ThanendrarajanC. SchinkeJ. EpsteinF. E. DaviesB. A. WalkerT. MeissnerB. BarlogieG. J. MorganN. WeinholdNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Rasche S. S. Chavan O. W. Stephens P. H. Patel R. Tytarenko C. Ashby M. Bauer C. Stein S. Deshpande C. Wardell T. Buzder G. Molnar M. Zangari F. van Rhee S. Thanendrarajan C. Schinke J. Epstein F. E. Davies B. A. Walker T. Meissner B. Barlogie G. J. Morgan N. Weinhold Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
description	In multiple myeloma, malignant cells expand within bone marrow. Here, the authors use multi-region sequencing in patient samples to analyse spatial clonal architecture and heterogeneity, providing novel insight into multiple myeloma progression and evolution.
format	article
author	L. Rasche S. S. Chavan O. W. Stephens P. H. Patel R. Tytarenko C. Ashby M. Bauer C. Stein S. Deshpande C. Wardell T. Buzder G. Molnar M. Zangari F. van Rhee S. Thanendrarajan C. Schinke J. Epstein F. E. Davies B. A. Walker T. Meissner B. Barlogie G. J. Morgan N. Weinhold
author_facet	L. Rasche S. S. Chavan O. W. Stephens P. H. Patel R. Tytarenko C. Ashby M. Bauer C. Stein S. Deshpande C. Wardell T. Buzder G. Molnar M. Zangari F. van Rhee S. Thanendrarajan C. Schinke J. Epstein F. E. Davies B. A. Walker T. Meissner B. Barlogie G. J. Morgan N. Weinhold
author_sort	L. Rasche
title	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
title_short	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
title_full	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
title_fullStr	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
title_full_unstemmed	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
title_sort	spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/606531925289417ab3689547176c20ed
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Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

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