Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.

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Autores principales:	Hongsheng Zhang, Eunchai Kang, Yaqing Wang, Chaojuan Yang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M. Christian, Hongjun Song, Guo-li Ming, Zhiheng Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/606608a70bca406f8d586bffd848128c
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spelling	oai:doaj.org-article:606608a70bca406f8d586bffd848128c2021-12-02T16:56:47ZBrain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice10.1038/ncomms117732041-1723https://doaj.org/article/606608a70bca406f8d586bffd848128c2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11773https://doaj.org/toc/2041-1723The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.Hongsheng ZhangEunchai KangYaqing WangChaojuan YangHui YuQin WangZheyu ChenChen ZhangKimberly M. ChristianHongjun SongGuo-li MingZhiheng XuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongsheng Zhang Eunchai Kang Yaqing Wang Chaojuan Yang Hui Yu Qin Wang Zheyu Chen Chen Zhang Kimberly M. Christian Hongjun Song Guo-li Ming Zhiheng Xu Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
description	The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.
format	article
author	Hongsheng Zhang Eunchai Kang Yaqing Wang Chaojuan Yang Hui Yu Qin Wang Zheyu Chen Chen Zhang Kimberly M. Christian Hongjun Song Guo-li Ming Zhiheng Xu
author_facet	Hongsheng Zhang Eunchai Kang Yaqing Wang Chaojuan Yang Hui Yu Qin Wang Zheyu Chen Chen Zhang Kimberly M. Christian Hongjun Song Guo-li Ming Zhiheng Xu
author_sort	Hongsheng Zhang
title	Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
title_short	Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
title_full	Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
title_fullStr	Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
title_full_unstemmed	Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
title_sort	brain-specific crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/606608a70bca406f8d586bffd848128c
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Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

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