Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.

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Bibliographic Details
Main Authors: Hongsheng Zhang, Eunchai Kang, Yaqing Wang, Chaojuan Yang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M. Christian, Hongjun Song, Guo-li Ming, Zhiheng Xu
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/606608a70bca406f8d586bffd848128c
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