The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms

Abstract We previously reported the CINSARC signature as a prognostic marker for metastatic events in soft tissue sarcomas, breast carcinomas and lymphomas through genomic instability, acting as a major factor for tumor aggressiveness. In this study, we used a published resource to investigate CINSA...

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Autores principales:	Tom Lesluyes, Lucile Delespaul, Jean-Michel Coindre, Frédéric Chibon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6067c8cad8f243099c0bcfe0a4eac9b9
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spelling	oai:doaj.org-article:6067c8cad8f243099c0bcfe0a4eac9b92021-12-02T12:32:03ZThe CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms10.1038/s41598-017-05726-x2045-2322https://doaj.org/article/6067c8cad8f243099c0bcfe0a4eac9b92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05726-xhttps://doaj.org/toc/2045-2322Abstract We previously reported the CINSARC signature as a prognostic marker for metastatic events in soft tissue sarcomas, breast carcinomas and lymphomas through genomic instability, acting as a major factor for tumor aggressiveness. In this study, we used a published resource to investigate CINSARC enrichment in poor outcome-associated genes at pan-cancer level and in 39 cancer types. CINSARC outperformed more than 15,000 defined signatures (including cancer-related), being enriched in top-ranked poor outcome-associated genes of 21 cancer types, widest coverage reached among all tested signatures. Independently, this signature demonstrated significant survival differences between risk-groups in 33 published studies, representing 17 tumor types. As a consequence, we propose the CINSARC prognostication as a general marker for tumor aggressiveness to optimize the clinical managements of patients.Tom LesluyesLucile DelespaulJean-Michel CoindreFrédéric ChibonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tom Lesluyes Lucile Delespaul Jean-Michel Coindre Frédéric Chibon The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
description	Abstract We previously reported the CINSARC signature as a prognostic marker for metastatic events in soft tissue sarcomas, breast carcinomas and lymphomas through genomic instability, acting as a major factor for tumor aggressiveness. In this study, we used a published resource to investigate CINSARC enrichment in poor outcome-associated genes at pan-cancer level and in 39 cancer types. CINSARC outperformed more than 15,000 defined signatures (including cancer-related), being enriched in top-ranked poor outcome-associated genes of 21 cancer types, widest coverage reached among all tested signatures. Independently, this signature demonstrated significant survival differences between risk-groups in 33 published studies, representing 17 tumor types. As a consequence, we propose the CINSARC prognostication as a general marker for tumor aggressiveness to optimize the clinical managements of patients.
format	article
author	Tom Lesluyes Lucile Delespaul Jean-Michel Coindre Frédéric Chibon
author_facet	Tom Lesluyes Lucile Delespaul Jean-Michel Coindre Frédéric Chibon
author_sort	Tom Lesluyes
title	The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
title_short	The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
title_full	The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
title_fullStr	The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
title_full_unstemmed	The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms
title_sort	cinsarc signature as a prognostic marker for clinical outcome in multiple neoplasms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6067c8cad8f243099c0bcfe0a4eac9b9
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The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms

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