Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis

Abstract Background Thymic tumors usually present with adjacent organ invasion or pleural dissemination, but very few studies have reported on occult pleural dissemination detected intraoperatively. This study aimed to investigate the risk factors that can predict pleural dissemination preoperativel...

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Autores principales:	Zuodong Song, Shu Zhu, Tangbing Chen, Weigang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Occult pleural dissemination Thymic tumor Intraoperatively Surgery RD1-811 Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/606a1846a9e749199f9d023c18cdbfa2
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spelling	oai:doaj.org-article:606a1846a9e749199f9d023c18cdbfa22021-11-21T12:33:51ZOccult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis10.1186/s13019-021-01717-21749-8090https://doaj.org/article/606a1846a9e749199f9d023c18cdbfa22021-11-01T00:00:00Zhttps://doi.org/10.1186/s13019-021-01717-2https://doaj.org/toc/1749-8090Abstract Background Thymic tumors usually present with adjacent organ invasion or pleural dissemination, but very few studies have reported on occult pleural dissemination detected intraoperatively. This study aimed to investigate the risk factors that can predict pleural dissemination preoperatively. Methods Consecutive patients with thymic tumors who underwent surgery from January 2010 to January 2017 were reviewed. Only patients without pleural dissemination detected preoperatively were included in this study. Demographic, clinical, pathological, and survival data were collected for statistical analysis. Further analyses were performed to find the risk factors of occult pleural dissemination. Results A total of 352 patients with thymic tumors were included in this study. Seven patients had pleural dissemination detected intraoperatively. All pleural dissemination cases were in clinical Masaoka-Koga stage III, and most underwent the video-assisted thoracoscopic surgery (VATS) approach (or VATS exploration). Univariate analysis showed that positive squamous cell carcinoma (SCC) antigen was the only predictor of pleural dissemination (p = 0.009). Tiny nodules close to the diaphragm were detected in the computed tomography scans of 1 case after reviewing the imaging data. Tumor recurrence occurred in 5 patients during follow-up. The disease-free survival rates were better in patients with a solitary nodule than those with multiple nodules (p = 0.019). No significant difference was detected in terms of disease-free survival rates between SCC antigen positive and SCC antigen negative patients. Conclusions Positive SCC antigen was the only detected risk factor for predicting pleural dissemination in thymic tumors preoperatively in this study. The VATS approach (including VATS exploration) is suggested for patients with clinical Masaoka-Koga stage III and SCC antigen positive thymic tumors, according to our experience.Zuodong SongShu ZhuTangbing ChenWeigang ZhaoBMCarticleOccult pleural disseminationThymic tumorIntraoperativelySurgeryRD1-811AnesthesiologyRD78.3-87.3ENJournal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Occult pleural dissemination Thymic tumor Intraoperatively Surgery RD1-811 Anesthesiology RD78.3-87.3
spellingShingle	Occult pleural dissemination Thymic tumor Intraoperatively Surgery RD1-811 Anesthesiology RD78.3-87.3 Zuodong Song Shu Zhu Tangbing Chen Weigang Zhao Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
description	Abstract Background Thymic tumors usually present with adjacent organ invasion or pleural dissemination, but very few studies have reported on occult pleural dissemination detected intraoperatively. This study aimed to investigate the risk factors that can predict pleural dissemination preoperatively. Methods Consecutive patients with thymic tumors who underwent surgery from January 2010 to January 2017 were reviewed. Only patients without pleural dissemination detected preoperatively were included in this study. Demographic, clinical, pathological, and survival data were collected for statistical analysis. Further analyses were performed to find the risk factors of occult pleural dissemination. Results A total of 352 patients with thymic tumors were included in this study. Seven patients had pleural dissemination detected intraoperatively. All pleural dissemination cases were in clinical Masaoka-Koga stage III, and most underwent the video-assisted thoracoscopic surgery (VATS) approach (or VATS exploration). Univariate analysis showed that positive squamous cell carcinoma (SCC) antigen was the only predictor of pleural dissemination (p = 0.009). Tiny nodules close to the diaphragm were detected in the computed tomography scans of 1 case after reviewing the imaging data. Tumor recurrence occurred in 5 patients during follow-up. The disease-free survival rates were better in patients with a solitary nodule than those with multiple nodules (p = 0.019). No significant difference was detected in terms of disease-free survival rates between SCC antigen positive and SCC antigen negative patients. Conclusions Positive SCC antigen was the only detected risk factor for predicting pleural dissemination in thymic tumors preoperatively in this study. The VATS approach (including VATS exploration) is suggested for patients with clinical Masaoka-Koga stage III and SCC antigen positive thymic tumors, according to our experience.
format	article
author	Zuodong Song Shu Zhu Tangbing Chen Weigang Zhao
author_facet	Zuodong Song Shu Zhu Tangbing Chen Weigang Zhao
author_sort	Zuodong Song
title	Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
title_short	Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
title_full	Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
title_fullStr	Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
title_full_unstemmed	Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
title_sort	occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/606a1846a9e749199f9d023c18cdbfa2
work_keys_str_mv	AT zuodongsong occultpleuraldisseminationdetectedintraoperativelyinpatientswiththymictumorsaretrospectiveanalysis AT shuzhu occultpleuraldisseminationdetectedintraoperativelyinpatientswiththymictumorsaretrospectiveanalysis AT tangbingchen occultpleuraldisseminationdetectedintraoperativelyinpatientswiththymictumorsaretrospectiveanalysis AT weigangzhao occultpleuraldisseminationdetectedintraoperativelyinpatientswiththymictumorsaretrospectiveanalysis
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Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis

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