The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats
Background: Cnidoscolus aconitifolius is widely used by traditional healers in treating plethora of ailments either alone, in combination with other therapeutic agents or as addictive to food/drinks. This study investigated the effect of different doses of C. aconitifolius on cardiorenal function in...
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Shiraz University of Medical Sciences
2021
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oai:doaj.org-article:606b5f6882d340a18dc4cbaa1cf38b402021-11-04T07:40:12ZThe Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats2538-18732538-282910.30476/ijns.2021.92067.1145https://doaj.org/article/606b5f6882d340a18dc4cbaa1cf38b402021-09-01T00:00:00Zhttps://ijns.sums.ac.ir/article_47807_00a68e0b5e35b5fc14ed41eb0297f78d.pdfhttps://doaj.org/toc/2538-1873https://doaj.org/toc/2538-2829Background: Cnidoscolus aconitifolius is widely used by traditional healers in treating plethora of ailments either alone, in combination with other therapeutic agents or as addictive to food/drinks. This study investigated the effect of different doses of C. aconitifolius on cardiorenal function in both normotensive and hypertensive male Wistar rats.Methods: Forty-two male Wistar rats (120-150 g) were categorized into two normotensive and hypertensive groups. Normotensive was group 1 receiving food and water; while normotensive groups 2 and 3 received food and water together with 200 mg and 800 mg of C. aconitifolius for 4 weeks. The hypertensive group 1 received only high salt diet (HSD) and water and hypertensive groups 2 and 3 received HSD and water together with 200 mg and 800 mg of C. aconitifolius, respectively for 4 weeks after confirmation of hypertension. The animals were sacrifice by cervical dislocation and blood sample was collected, and serum was decanted for assays; while heart and kidney were harvested for histological investigation.Results: There were significant reductions in systolic, diastolic and mean arterial blood pressure in hypertensive animals; while was not different in normotensive animals. Urine creatinine and fractional excretion decreased; while the histomorphology of the heart in hypertensive animals showed restorative and regenerative effects of C. aconitifolius.Conclusion: This study suggests that C. aconitifolius potentiates cardiorenal functions by affecting the functional markers, as well as histology.Damilola AlawodeJerome AsiweEmuesiri MokeDavid OkonofuaKamaldeen SanusiEbunoluwa AdagbadaMariam YusufAdesoji FasanmadeShiraz University of Medical Sciencesarticlecnidosculus aconitifoliuscardiorenalhypertensioncreatinineratNutritional diseases. Deficiency diseasesRC620-627ENInternational Journal of Nutrition Sciences, Vol 6, Iss 3, Pp 155-160 (2021) |
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cnidosculus aconitifolius cardiorenal hypertension creatinine rat Nutritional diseases. Deficiency diseases RC620-627 |
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cnidosculus aconitifolius cardiorenal hypertension creatinine rat Nutritional diseases. Deficiency diseases RC620-627 Damilola Alawode Jerome Asiwe Emuesiri Moke David Okonofua Kamaldeen Sanusi Ebunoluwa Adagbada Mariam Yusuf Adesoji Fasanmade The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| description |
Background: Cnidoscolus aconitifolius is widely used by traditional healers in treating plethora of ailments either alone, in combination with other therapeutic agents or as addictive to food/drinks. This study investigated the effect of different doses of C. aconitifolius on cardiorenal function in both normotensive and hypertensive male Wistar rats.Methods: Forty-two male Wistar rats (120-150 g) were categorized into two normotensive and hypertensive groups. Normotensive was group 1 receiving food and water; while normotensive groups 2 and 3 received food and water together with 200 mg and 800 mg of C. aconitifolius for 4 weeks. The hypertensive group 1 received only high salt diet (HSD) and water and hypertensive groups 2 and 3 received HSD and water together with 200 mg and 800 mg of C. aconitifolius, respectively for 4 weeks after confirmation of hypertension. The animals were sacrifice by cervical dislocation and blood sample was collected, and serum was decanted for assays; while heart and kidney were harvested for histological investigation.Results: There were significant reductions in systolic, diastolic and mean arterial blood pressure in hypertensive animals; while was not different in normotensive animals. Urine creatinine and fractional excretion decreased; while the histomorphology of the heart in hypertensive animals showed restorative and regenerative effects of C. aconitifolius.Conclusion: This study suggests that C. aconitifolius potentiates cardiorenal functions by affecting the functional markers, as well as histology. |
| format |
article |
| author |
Damilola Alawode Jerome Asiwe Emuesiri Moke David Okonofua Kamaldeen Sanusi Ebunoluwa Adagbada Mariam Yusuf Adesoji Fasanmade |
| author_facet |
Damilola Alawode Jerome Asiwe Emuesiri Moke David Okonofua Kamaldeen Sanusi Ebunoluwa Adagbada Mariam Yusuf Adesoji Fasanmade |
| author_sort |
Damilola Alawode |
| title |
The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| title_short |
The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| title_full |
The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| title_fullStr |
The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| title_full_unstemmed |
The Effect of Ethanol Leaf Extract of Cnidosculus Aconitifolius on Cardiorenal Functions in Hypertensive and Normotensive Male Wistar Rats |
| title_sort |
effect of ethanol leaf extract of cnidosculus aconitifolius on cardiorenal functions in hypertensive and normotensive male wistar rats |
| publisher |
Shiraz University of Medical Sciences |
| publishDate |
2021 |
| url |
https://doaj.org/article/606b5f6882d340a18dc4cbaa1cf38b40 |
| work_keys_str_mv |
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