Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).

The global migration patterns of influenza viruses have profound implications for the evolutionary and epidemiological dynamics of the disease. We developed a novel approach to reconstruct the genetic history of human influenza A (H3N2) collected worldwide over 1998 to 2009 and used it to infer the...

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Autores principales:	Trevor Bedford, Sarah Cobey, Peter Beerli, Mercedes Pascual
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/606c882d783f49b4bb01cc943ffce409
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spelling	oai:doaj.org-article:606c882d783f49b4bb01cc943ffce4092021-12-02T20:00:38ZGlobal migration dynamics underlie evolution and persistence of human influenza A (H3N2).1553-73661553-737410.1371/journal.ppat.1000918https://doaj.org/article/606c882d783f49b4bb01cc943ffce4092010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20523898/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The global migration patterns of influenza viruses have profound implications for the evolutionary and epidemiological dynamics of the disease. We developed a novel approach to reconstruct the genetic history of human influenza A (H3N2) collected worldwide over 1998 to 2009 and used it to infer the global network of influenza transmission. Consistent with previous models, we find that China and Southeast Asia lie at the center of this global network. However, we also find that strains of influenza circulate outside of Asia for multiple seasons, persisting through dynamic migration between northern and southern regions. The USA acts as the primary hub of temperate transmission and, together with China and Southeast Asia, forms the trunk of influenza's evolutionary tree. These findings suggest that antiviral use outside of China and Southeast Asia may lead to the evolution of long-term local and potentially global antiviral resistance. Our results might also aid the design of surveillance efforts and of vaccines better tailored to different geographic regions.Trevor BedfordSarah CobeyPeter BeerliMercedes PascualPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 5, p e1000918 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Trevor Bedford Sarah Cobey Peter Beerli Mercedes Pascual Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
description	The global migration patterns of influenza viruses have profound implications for the evolutionary and epidemiological dynamics of the disease. We developed a novel approach to reconstruct the genetic history of human influenza A (H3N2) collected worldwide over 1998 to 2009 and used it to infer the global network of influenza transmission. Consistent with previous models, we find that China and Southeast Asia lie at the center of this global network. However, we also find that strains of influenza circulate outside of Asia for multiple seasons, persisting through dynamic migration between northern and southern regions. The USA acts as the primary hub of temperate transmission and, together with China and Southeast Asia, forms the trunk of influenza's evolutionary tree. These findings suggest that antiviral use outside of China and Southeast Asia may lead to the evolution of long-term local and potentially global antiviral resistance. Our results might also aid the design of surveillance efforts and of vaccines better tailored to different geographic regions.
format	article
author	Trevor Bedford Sarah Cobey Peter Beerli Mercedes Pascual
author_facet	Trevor Bedford Sarah Cobey Peter Beerli Mercedes Pascual
author_sort	Trevor Bedford
title	Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
title_short	Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
title_full	Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
title_fullStr	Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
title_full_unstemmed	Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
title_sort	global migration dynamics underlie evolution and persistence of human influenza a (h3n2).
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/606c882d783f49b4bb01cc943ffce409
work_keys_str_mv	AT trevorbedford globalmigrationdynamicsunderlieevolutionandpersistenceofhumaninfluenzaah3n2 AT sarahcobey globalmigrationdynamicsunderlieevolutionandpersistenceofhumaninfluenzaah3n2 AT peterbeerli globalmigrationdynamicsunderlieevolutionandpersistenceofhumaninfluenzaah3n2 AT mercedespascual globalmigrationdynamicsunderlieevolutionandpersistenceofhumaninfluenzaah3n2
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Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).

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