Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes

The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.

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Autores principales:	Andreas Porse, Leonie J. Jahn, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/606e123abcb44a1d8324f2a0a0dd1190
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spelling	oai:doaj.org-article:606e123abcb44a1d8324f2a0a0dd11902021-12-02T16:49:46ZDominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes10.1038/s41467-020-15080-82041-1723https://doaj.org/article/606e123abcb44a1d8324f2a0a0dd11902020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15080-8https://doaj.org/toc/2041-1723The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.Andreas PorseLeonie J. JahnMostafa M. H. EllabaanMorten O. A. SommerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
description	The authors study the interactions between chromosomal mutations and horizontally acquired genes in the evolution of antibiotic resistance in experimental evolution assays. They identify constraints that may allow better prediction and control of antibiotic resistance evolution.
format	article
author	Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer
author_facet	Andreas Porse Leonie J. Jahn Mostafa M. H. Ellabaan Morten O. A. Sommer
author_sort	Andreas Porse
title	Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_short	Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_full	Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_fullStr	Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_full_unstemmed	Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
title_sort	dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/606e123abcb44a1d8324f2a0a0dd1190
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Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes

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