A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

Lipid nanoparticle delivery of mRNA vaccines has become of particular importance, however, mRNA stability is a major concern. Here, the authors report on a study of lipid impurity mRNA interactions using reverse phase ion pair HPLC to identify reactions which render the mRNA untranslatable, reducing...

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Main Authors: Meredith Packer, Dipendra Gyawali, Ravikiran Yerabolu, Joseph Schariter, Phil White
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/6070fe973ed84518bd7e807ce4b6bad9
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spelling oai:doaj.org-article:6070fe973ed84518bd7e807ce4b6bad92021-11-28T12:34:51ZA novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems10.1038/s41467-021-26926-02041-1723https://doaj.org/article/6070fe973ed84518bd7e807ce4b6bad92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26926-0https://doaj.org/toc/2041-1723Lipid nanoparticle delivery of mRNA vaccines has become of particular importance, however, mRNA stability is a major concern. Here, the authors report on a study of lipid impurity mRNA interactions using reverse phase ion pair HPLC to identify reactions which render the mRNA untranslatable, reducing vaccine efficiency.Meredith PackerDipendra GyawaliRavikiran YeraboluJoseph SchariterPhil WhiteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Meredith Packer
Dipendra Gyawali
Ravikiran Yerabolu
Joseph Schariter
Phil White
A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
description Lipid nanoparticle delivery of mRNA vaccines has become of particular importance, however, mRNA stability is a major concern. Here, the authors report on a study of lipid impurity mRNA interactions using reverse phase ion pair HPLC to identify reactions which render the mRNA untranslatable, reducing vaccine efficiency.
format article
author Meredith Packer
Dipendra Gyawali
Ravikiran Yerabolu
Joseph Schariter
Phil White
author_facet Meredith Packer
Dipendra Gyawali
Ravikiran Yerabolu
Joseph Schariter
Phil White
author_sort Meredith Packer
title A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
title_short A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
title_full A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
title_fullStr A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
title_full_unstemmed A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
title_sort novel mechanism for the loss of mrna activity in lipid nanoparticle delivery systems
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6070fe973ed84518bd7e807ce4b6bad9
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AT ravikiranyerabolu anovelmechanismforthelossofmrnaactivityinlipidnanoparticledeliverysystems
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