Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults

Epidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect of PM2.5 on BP, HR and the mediation effect of related inflammation biomarkers. A to...

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Autores principales:	Zhaoyuan Li, Yisi Liu, Tianjun Lu, Shouxin Peng, Feifei Liu, Jinhui Sun, Hao Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Individual PM2.5 exposure Acute effect Heart rate Fibrinogen Mediation effect Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/60756e15fc5143eeb5437337fc9c8fe2
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spelling	oai:doaj.org-article:60756e15fc5143eeb5437337fc9c8fe22021-11-26T04:23:32ZAcute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults0147-651310.1016/j.ecoenv.2021.113024https://doaj.org/article/60756e15fc5143eeb5437337fc9c8fe22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011362https://doaj.org/toc/0147-6513Epidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect of PM2.5 on BP, HR and the mediation effect of related inflammation biomarkers. A total of 32 healthy college students were recruited to perform 4 h of exposure at two sites with different PM2.5 concentrations in Wuhan between May 2019 and June 2019. The individual levels of PM2.5 concentration, BP and HR were measured hourly for each participant. Blood was drawn from each participant after each visit and we measured the levels of inflammation markers, including serum high-sensitivity C-reactive protein and plasma fibrinogen. Linear mixed-effect models were to explore the acute effect of PM2.5 exposure on BP, HR, and related inflammation biomarkers. In addition, we evaluated related inflammation biomarkers as the mediator in the association of PM2.5 and cardiovascular health indicators. The results showed that a 10 μg/m3 increment in PM2.5 concentration was associated with an increase of 0.84 (95% CI: 0.54, 1.15) beats/min (bpm) in HR and a 3.52% (95% CI: 1.60%, 5.48%) increase in fibrinogen. The lag effect model showed that the strongest effect on HR was observed at lag 3 h of PM2.5 exposure [1.96 bpm (95% CI: 1.19, 2.75)], but for fibrinogen, delayed exposure attenuated the association. Increased fibrinogen levels may account for 39.07% (P = 0.44) of the elevated HR by PM2.5. Null association was observed when it comes to short-term PM2.5 exposure and BP. Short-term exposure to PM2.5 was associated with elevated HR and increased fibrinogen levels. But our finding was not enough to suggest that exposure to PM2.5 might induce adverse cardiovascular effects by the pathway of inflammation.Zhaoyuan LiYisi LiuTianjun LuShouxin PengFeifei LiuJinhui SunHao XiangElsevierarticleIndividual PM2.5 exposureAcute effectHeart rateFibrinogenMediation effectEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113024- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Individual PM2.5 exposure Acute effect Heart rate Fibrinogen Mediation effect Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Individual PM2.5 exposure Acute effect Heart rate Fibrinogen Mediation effect Environmental pollution TD172-193.5 Environmental sciences GE1-350 Zhaoyuan Li Yisi Liu Tianjun Lu Shouxin Peng Feifei Liu Jinhui Sun Hao Xiang Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
description	Epidemiological evidence of short-term fine particulate matter (PM2.5) exposure on blood pressure (BP), heart rate (HR) and related inflammation biomarkers has been inconsistent. We aimed to explore the acute effect of PM2.5 on BP, HR and the mediation effect of related inflammation biomarkers. A total of 32 healthy college students were recruited to perform 4 h of exposure at two sites with different PM2.5 concentrations in Wuhan between May 2019 and June 2019. The individual levels of PM2.5 concentration, BP and HR were measured hourly for each participant. Blood was drawn from each participant after each visit and we measured the levels of inflammation markers, including serum high-sensitivity C-reactive protein and plasma fibrinogen. Linear mixed-effect models were to explore the acute effect of PM2.5 exposure on BP, HR, and related inflammation biomarkers. In addition, we evaluated related inflammation biomarkers as the mediator in the association of PM2.5 and cardiovascular health indicators. The results showed that a 10 μg/m3 increment in PM2.5 concentration was associated with an increase of 0.84 (95% CI: 0.54, 1.15) beats/min (bpm) in HR and a 3.52% (95% CI: 1.60%, 5.48%) increase in fibrinogen. The lag effect model showed that the strongest effect on HR was observed at lag 3 h of PM2.5 exposure [1.96 bpm (95% CI: 1.19, 2.75)], but for fibrinogen, delayed exposure attenuated the association. Increased fibrinogen levels may account for 39.07% (P = 0.44) of the elevated HR by PM2.5. Null association was observed when it comes to short-term PM2.5 exposure and BP. Short-term exposure to PM2.5 was associated with elevated HR and increased fibrinogen levels. But our finding was not enough to suggest that exposure to PM2.5 might induce adverse cardiovascular effects by the pathway of inflammation.
format	article
author	Zhaoyuan Li Yisi Liu Tianjun Lu Shouxin Peng Feifei Liu Jinhui Sun Hao Xiang
author_facet	Zhaoyuan Li Yisi Liu Tianjun Lu Shouxin Peng Feifei Liu Jinhui Sun Hao Xiang
author_sort	Zhaoyuan Li
title	Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
title_short	Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
title_full	Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
title_fullStr	Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
title_full_unstemmed	Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults
title_sort	acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: a panel study in healthy adults
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/60756e15fc5143eeb5437337fc9c8fe2
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Acute effect of fine particulate matter on blood pressure, heart rate and related inflammation biomarkers: A panel study in healthy adults

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