A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).

<h4>Objective</h4>To develop a whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM), and to predict progression across different severity states using OA-COM as outcome and clinical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eric C Sayre, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Jacek A Kopec, Joel Singer, Hubert Wong, Anona Thorne, Jolanda Cibere
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6077ab0ad4b14ad1bd3c27ad0fcde5ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6077ab0ad4b14ad1bd3c27ad0fcde5ba
record_format	dspace
spelling	oai:doaj.org-article:6077ab0ad4b14ad1bd3c27ad0fcde5ba2021-12-02T20:19:14ZA whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).1932-620310.1371/journal.pone.0258451https://doaj.org/article/6077ab0ad4b14ad1bd3c27ad0fcde5ba2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258451https://doaj.org/toc/1932-6203<h4>Objective</h4>To develop a whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM), and to predict progression across different severity states using OA-COM as outcome and clinical variables as predictors.<h4>Methods</h4>Population-based knee pain cohort aged 40-79 was assessed at baseline and 7-year follow-up. OA-COM score was defined as the sum of MRI scores for cartilage, osteophytes and menisci, measured at 6, 8 and 6 sites, total score 0-54. To anchor severity levels, we fit cross-sectional logistic models using OA-COM to predict Kellgren-Lawrence (KL) grades in subsets at or one point below each grade. OA-COM threshold scores were selected on sensitivity, specificity, positive and negative predictive value. We developed longitudinal logistic models for OA-COM progression over each threshold over 7 years. Potential predictors included age, sex, BMI, malalignment, physical exam effusion, quadriceps weakness, and crepitus, selected on area under the receiver operating characteristic curve (AUC) and Akaike's Information Criterion (AIC).<h4>Results</h4>Optimal OA-COM thresholds were 12, 18, 24 and 30, for KL grades 1 to 4. Significant predictors of progression (depending on threshold) included physical exam effusion, malalignment and female sex, with other selected predictors age, BMI and crepitus.<h4>Conclusion</h4>OA-COM (0-54 range) is a whole-joint, unidimensional, irreversible, and fine-grained MRI OA severity score reflecting cartilage, osteophytes and menisci. OA-COM scores 12, 18, 24 and 30 are equivalent to KL grades 1 to 4, while offering fine-grained differentiation of states between KL grades, and within pre-radiographic disease (KL = 0) or late-stage disease (KL = 4). In modeling, several clinical variables predicted progression across different states over 7 years.Eric C SayreAli GuermaziSavvas NicolaouJohn M EsdaileJacek A KopecJoel SingerHubert WongAnona ThorneJolanda CiberePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258451 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eric C Sayre Ali Guermazi Savvas Nicolaou John M Esdaile Jacek A Kopec Joel Singer Hubert Wong Anona Thorne Jolanda Cibere A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
description	<h4>Objective</h4>To develop a whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM), and to predict progression across different severity states using OA-COM as outcome and clinical variables as predictors.<h4>Methods</h4>Population-based knee pain cohort aged 40-79 was assessed at baseline and 7-year follow-up. OA-COM score was defined as the sum of MRI scores for cartilage, osteophytes and menisci, measured at 6, 8 and 6 sites, total score 0-54. To anchor severity levels, we fit cross-sectional logistic models using OA-COM to predict Kellgren-Lawrence (KL) grades in subsets at or one point below each grade. OA-COM threshold scores were selected on sensitivity, specificity, positive and negative predictive value. We developed longitudinal logistic models for OA-COM progression over each threshold over 7 years. Potential predictors included age, sex, BMI, malalignment, physical exam effusion, quadriceps weakness, and crepitus, selected on area under the receiver operating characteristic curve (AUC) and Akaike's Information Criterion (AIC).<h4>Results</h4>Optimal OA-COM thresholds were 12, 18, 24 and 30, for KL grades 1 to 4. Significant predictors of progression (depending on threshold) included physical exam effusion, malalignment and female sex, with other selected predictors age, BMI and crepitus.<h4>Conclusion</h4>OA-COM (0-54 range) is a whole-joint, unidimensional, irreversible, and fine-grained MRI OA severity score reflecting cartilage, osteophytes and menisci. OA-COM scores 12, 18, 24 and 30 are equivalent to KL grades 1 to 4, while offering fine-grained differentiation of states between KL grades, and within pre-radiographic disease (KL = 0) or late-stage disease (KL = 4). In modeling, several clinical variables predicted progression across different states over 7 years.
format	article
author	Eric C Sayre Ali Guermazi Savvas Nicolaou John M Esdaile Jacek A Kopec Joel Singer Hubert Wong Anona Thorne Jolanda Cibere
author_facet	Eric C Sayre Ali Guermazi Savvas Nicolaou John M Esdaile Jacek A Kopec Joel Singer Hubert Wong Anona Thorne Jolanda Cibere
author_sort	Eric C Sayre
title	A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
title_short	A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
title_full	A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
title_fullStr	A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
title_full_unstemmed	A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).
title_sort	whole-joint, unidimensional, irreversible, and fine-grained mri knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (oa-com).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6077ab0ad4b14ad1bd3c27ad0fcde5ba
work_keys_str_mv	AT ericcsayre awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT aliguermazi awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT savvasnicolaou awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT johnmesdaile awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT jacekakopec awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT joelsinger awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT hubertwong awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT anonathorne awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT jolandacibere awholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT ericcsayre wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT aliguermazi wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT savvasnicolaou wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT johnmesdaile wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT jacekakopec wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT joelsinger wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT hubertwong wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT anonathorne wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom AT jolandacibere wholejointunidimensionalirreversibleandfinegrainedmrikneeosteoarthritisseverityscorebasedoncartilageosteophytesandmeniscusoacom
_version_	1718374227137003520

A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).

Ejemplares similares