UMOD Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study

We aimed to explore associations of several single nucleotide polymorphisms (SNPs) detected by genome-wide association studies in uromodulin (UMOD) gene with phenotypes and prognosis of chronic kidney disease (CKD) among 2731 Chinese patients with CKD stage 1–4....

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Autores principales:	Jinwei Wang, Lili Liu, Kevin He, Bixia Gao, Fang Wang, Minghui Zhao, Luxia Zhang, on behalf of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	all-cause mortality chronic kidney disease genetic association outcomes single nucleotide polymorphism <i>UMOD</i> gene Genetics QH426-470
Acceso en línea:	https://doaj.org/article/6077d87a166d4e169b94cb506df9a673
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spelling	oai:doaj.org-article:6077d87a166d4e169b94cb506df9a6732021-11-25T17:40:49Z<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study10.3390/genes121116872073-4425https://doaj.org/article/6077d87a166d4e169b94cb506df9a6732021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1687https://doaj.org/toc/2073-4425We aimed to explore associations of several single nucleotide polymorphisms (SNPs) detected by genome-wide association studies in <i>uromodulin</i> (<i>UMOD</i>) gene with phenotypes and prognosis of chronic kidney disease (CKD) among 2731 Chinese patients with CKD stage 1–4. Polymorphisms of rs11864909, rs4293393, rs6497476, and rs13333226 were genotyped using the Sequenom MassARRAY iPLEX platform. The SNPs of rs13333226 and rs4293393 were in complete linkage disequilibrium. Based on the T dominant model, T allele of rs11864909 was associated with levels of estimated glomerular filtration rate (eGFR) and serum uromodulin with linear regression coefficients of 2.68 (95% confidence interval (CI): 0.61, 4.96) and −12.95 (95% CI: −17.59, −7.98), respectively, after adjustment for cardiovascular and kidney-specific risk factors. After a median follow-up of 4.94 years, both G allele of rs4293393/rs13333226 and C allele of rs6497476 were associated with reduced risk of all-cause mortality with multivariable-adjusted hazard ratios of 0.341 (95% CI: 0.105, 0.679) and 0.344 (95% CI: 0.104, 0.671), respectively. However, no associations were found between the variants and slope of eGFR in the linear mix effect model. In summary, the variant of rs11864909 in the UMOD gene was associated with levels of eGFR and serum uromodulin, while those of rs4293393 and rs6497476 were associated with all-cause mortality among patients with CKD.Jinwei WangLili LiuKevin HeBixia GaoFang WangMinghui ZhaoLuxia Zhangon behalf of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)MDPI AGarticleall-cause mortalitychronic kidney diseasegenetic associationoutcomessingle nucleotide polymorphism<i>UMOD</i> geneGeneticsQH426-470ENGenes, Vol 12, Iss 1687, p 1687 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	all-cause mortality chronic kidney disease genetic association outcomes single nucleotide polymorphism <i>UMOD</i> gene Genetics QH426-470
spellingShingle	all-cause mortality chronic kidney disease genetic association outcomes single nucleotide polymorphism <i>UMOD</i> gene Genetics QH426-470 Jinwei Wang Lili Liu Kevin He Bixia Gao Fang Wang Minghui Zhao Luxia Zhang on behalf of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) <i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
description	We aimed to explore associations of several single nucleotide polymorphisms (SNPs) detected by genome-wide association studies in <i>uromodulin</i> (<i>UMOD</i>) gene with phenotypes and prognosis of chronic kidney disease (CKD) among 2731 Chinese patients with CKD stage 1–4. Polymorphisms of rs11864909, rs4293393, rs6497476, and rs13333226 were genotyped using the Sequenom MassARRAY iPLEX platform. The SNPs of rs13333226 and rs4293393 were in complete linkage disequilibrium. Based on the T dominant model, T allele of rs11864909 was associated with levels of estimated glomerular filtration rate (eGFR) and serum uromodulin with linear regression coefficients of 2.68 (95% confidence interval (CI): 0.61, 4.96) and −12.95 (95% CI: −17.59, −7.98), respectively, after adjustment for cardiovascular and kidney-specific risk factors. After a median follow-up of 4.94 years, both G allele of rs4293393/rs13333226 and C allele of rs6497476 were associated with reduced risk of all-cause mortality with multivariable-adjusted hazard ratios of 0.341 (95% CI: 0.105, 0.679) and 0.344 (95% CI: 0.104, 0.671), respectively. However, no associations were found between the variants and slope of eGFR in the linear mix effect model. In summary, the variant of rs11864909 in the UMOD gene was associated with levels of eGFR and serum uromodulin, while those of rs4293393 and rs6497476 were associated with all-cause mortality among patients with CKD.
format	article
author	Jinwei Wang Lili Liu Kevin He Bixia Gao Fang Wang Minghui Zhao Luxia Zhang on behalf of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
author_facet	Jinwei Wang Lili Liu Kevin He Bixia Gao Fang Wang Minghui Zhao Luxia Zhang on behalf of the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
author_sort	Jinwei Wang
title	<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
title_short	<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
title_full	<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
title_fullStr	<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
title_full_unstemmed	<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study
title_sort	<i>umod</i> polymorphisms associated with kidney function, serum uromodulin and risk of mortality among patients with chronic kidney disease, results from the c-stride study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6077d87a166d4e169b94cb506df9a673
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<i>UMOD</i> Polymorphisms Associated with Kidney Function, Serum Uromodulin and Risk of Mortality among Patients with Chronic Kidney Disease, Results from the C-STRIDE Study

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