HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate on serine residues.

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Autores principales:	Marie-France Langelier, Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, John M. Pascal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6078d4725d6843d48dcd1bc9e7b93b53
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spelling	oai:doaj.org-article:6078d4725d6843d48dcd1bc9e7b93b532021-11-21T12:35:29ZHPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications10.1038/s41467-021-27043-82041-1723https://doaj.org/article/6078d4725d6843d48dcd1bc9e7b93b532021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27043-8https://doaj.org/toc/2041-1723HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate on serine residues.Marie-France LangelierRamya BillurAleksandr SverzhinskyBen E. BlackJohn M. PascalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie-France Langelier Ramya Billur Aleksandr Sverzhinsky Ben E. Black John M. Pascal HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
description	HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate on serine residues.
format	article
author	Marie-France Langelier Ramya Billur Aleksandr Sverzhinsky Ben E. Black John M. Pascal
author_facet	Marie-France Langelier Ramya Billur Aleksandr Sverzhinsky Ben E. Black John M. Pascal
author_sort	Marie-France Langelier
title	HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
title_short	HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
title_full	HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
title_fullStr	HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
title_full_unstemmed	HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
title_sort	hpf1 dynamically controls the parp1/2 balance between initiating and elongating adp-ribose modifications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6078d4725d6843d48dcd1bc9e7b93b53
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HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

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