HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate on serine residues.

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Detalles Bibliográficos
Autores principales: Marie-France Langelier, Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, John M. Pascal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6078d4725d6843d48dcd1bc9e7b93b53
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