Nanofunctionalized zirconia and barium sulfate particles as bone cement additives

Riaz Gillani1, Batur Ercan1, Alex Qiao3, Thomas J Webster1,21Division of Engineering, 2Department of Orthopaedics, Brown University, Providence, RI, USA; 3G3 Technology Innovations, LLC, Pittsford, NY, USAAbstract: Zirconia (ZrO2) and barium sulfate (BaSO4) particles were introduced into a methyl me...

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Autores principales:	Riaz Gillani, Batur Ercan, Alex Qiao, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/607f60b96dcd4c00ba2dedae951f6d0a
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spelling	oai:doaj.org-article:607f60b96dcd4c00ba2dedae951f6d0a2021-12-02T05:07:53ZNanofunctionalized zirconia and barium sulfate particles as bone cement additives1176-91141178-2013https://doaj.org/article/607f60b96dcd4c00ba2dedae951f6d0a2009-12-01T00:00:00Zhttp://www.dovepress.com/nanofunctionalized-zirconia-and-barium-sulfate-particles-as-bone-cemen-a3845https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Riaz Gillani1, Batur Ercan1, Alex Qiao3, Thomas J Webster1,21Division of Engineering, 2Department of Orthopaedics, Brown University, Providence, RI, USA; 3G3 Technology Innovations, LLC, Pittsford, NY, USAAbstract: Zirconia (ZrO2) and barium sulfate (BaSO4) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO2 micron particles, bone cements with unfunctionalized ZrO2 nanoparticles, bone cements with ZrO2 nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO4 micron particles, bone cements with unfunctionalized BaSO4 nanoparticles, and bone cements with BaSO4 nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO4 ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.Keywords: orthopedic, nanotechnology, bone cements, osteoblasts Riaz GillaniBatur ErcanAlex Qiaoet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 1-11 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Riaz Gillani Batur Ercan Alex Qiao et al Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
description	Riaz Gillani1, Batur Ercan1, Alex Qiao3, Thomas J Webster1,21Division of Engineering, 2Department of Orthopaedics, Brown University, Providence, RI, USA; 3G3 Technology Innovations, LLC, Pittsford, NY, USAAbstract: Zirconia (ZrO2) and barium sulfate (BaSO4) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO2 micron particles, bone cements with unfunctionalized ZrO2 nanoparticles, bone cements with ZrO2 nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO4 micron particles, bone cements with unfunctionalized BaSO4 nanoparticles, and bone cements with BaSO4 nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO4 ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.Keywords: orthopedic, nanotechnology, bone cements, osteoblasts
format	article
author	Riaz Gillani Batur Ercan Alex Qiao et al
author_facet	Riaz Gillani Batur Ercan Alex Qiao et al
author_sort	Riaz Gillani
title	Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
title_short	Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
title_full	Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
title_fullStr	Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
title_full_unstemmed	Nanofunctionalized zirconia and barium sulfate particles as bone cement additives
title_sort	nanofunctionalized zirconia and barium sulfate particles as bone cement additives
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/607f60b96dcd4c00ba2dedae951f6d0a
work_keys_str_mv	AT riazgillani nanofunctionalizedzirconiaandbariumsulfateparticlesasbonecementadditives AT baturercan nanofunctionalizedzirconiaandbariumsulfateparticlesasbonecementadditives AT alexqiao nanofunctionalizedzirconiaandbariumsulfateparticlesasbonecementadditives AT etal nanofunctionalizedzirconiaandbariumsulfateparticlesasbonecementadditives
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Nanofunctionalized zirconia and barium sulfate particles as bone cement additives

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