LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Da-Hye Lee, Jae Oh Park, Tae-Shin Kim, Sang-Kyum Kim, Tack-hoon Kim, Min-chul Kim, Gun Soo Park, Jeong-Hwan Kim, Shinji Kuninaka, Eric N. Olson, Hideyuki Saya, Seon-Young Kim, Ho Lee, Dae-Sik Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/608124d888234a85a5fb09ba2ac76500
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:608124d888234a85a5fb09ba2ac76500
record_format	dspace
spelling	oai:doaj.org-article:608124d888234a85a5fb09ba2ac765002021-12-02T15:34:09ZLATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development10.1038/ncomms119612041-1723https://doaj.org/article/608124d888234a85a5fb09ba2ac765002016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11961https://doaj.org/toc/2041-1723The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.Da-Hye LeeJae Oh ParkTae-Shin KimSang-Kyum KimTack-hoon KimMin-chul KimGun Soo ParkJeong-Hwan KimShinji KuninakaEric N. OlsonHideyuki SayaSeon-Young KimHo LeeDae-Sik LimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
description	The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.
format	article
author	Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim
author_facet	Da-Hye Lee Jae Oh Park Tae-Shin Kim Sang-Kyum Kim Tack-hoon Kim Min-chul Kim Gun Soo Park Jeong-Hwan Kim Shinji Kuninaka Eric N. Olson Hideyuki Saya Seon-Young Kim Ho Lee Dae-Sik Lim
author_sort	Da-Hye Lee
title	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
title_short	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
title_full	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
title_fullStr	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
title_full_unstemmed	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
title_sort	lats-yap/taz controls lineage specification by regulating tgfβ signaling and hnf4α expression during liver development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/608124d888234a85a5fb09ba2ac76500
work_keys_str_mv	AT dahyelee latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT jaeohpark latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT taeshinkim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT sangkyumkim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT tackhoonkim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT minchulkim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT gunsoopark latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT jeonghwankim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT shinjikuninaka latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT ericnolson latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT hideyukisaya latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT seonyoungkim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT holee latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment AT daesiklim latsyaptazcontrolslineagespecificationbyregulatingtgfbsignalingandhnf4aexpressionduringliverdevelopment
_version_	1718386902326837248

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

Ejemplares similares